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Indications/Uses
Treatment of infections of the upper & lower resp tract, skin & soft tissues & infections of the genitals due to Chlamydia trachomatis.
Dosage/Direction for Use
Adult including the elderly, childn & adolescent >45 kg Total dosage: 1,500 mg over 3 days (500 mg once daily) or over 5 days (500 mg as single dose on the 1st day & thereafter 250 mg once daily). Uncomplicated Chlamydia trachomatis urethritis & cervicitis 1000 mg as single dose.
Administration
May be taken with or without food: May be taken w/ meals to reduce GI discomfort.
Contraindications
Hypersensitivity to azithromycin monohydrate, erythromycin, any macrolide or ketolide antibiotic.
Special Precautions
Allergic reactions including angioedema & anaphylaxis. Significant hepatic disease. Monitor liver function tests. Co-administration w/ ergot derivatives. Consider Clostridium difficile associated diarrhea (CDAD) in patients who present w/ diarrhea after use. Severe renal impairment (GFR <10 mL/min); congenital or documented QT prolongation, currently receiving treatment w/ other active substances known to prolong QT interval eg, class IA & III antiarrhythmics, cisapride & terfenadine, electrolyte disturbance particularly in cases of hypokalemia & hypomagnesemia, clinically relevant bradycardia, cardiac arrhythmia or severe cardiac insufficiency. Exacerbations of myasthenia gravis symptoms. Not for prevention or treatment of Mycobacterium avium complex in childn. Rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Pregnancy & lactation. Childn & adolescents <45 kg.
Adverse Reactions
Diarrhea, abdominal pain, nausea, flatulence. Anorexia, dizziness, headache, paresthesia, dysgeusia, visual impairment, deafness, vomiting, dyspepsia, rash, pruritus, arthralgia, fatigue, decreased lymphocyte count, increased eosinophil count, decreased blood bicarbonate.
Drug Interactions
Reduced peak serum conc w/ antacids. Increased digoxin & cyclosporin levels. Possibility of ergotism w/ ergot derivatives. Increased conc of zidovudine. Potentiated anticoagulation w/ coumarin-type oral anticoagulants. Decreased Cmax w/ fluconazole. Neutropenia w/ rifabutin.
MedsGo Class
Macrolides
Features
Brand
RiteMed
Full Details
Dosage Strength
500mg
Drug Ingredients
- Azithromycin
Drug Packaging
Film-Coated Tablet 1's
Generic Name
Azithromycin Monohydrate
Dosage Form
Film-Coated Tablet
Registration Number
DRP-1286-02
Drug Classification
Prescription Drug (RX)