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Indications/Uses
Tuberculosis in all forms, leprosy, infections caused by rifampicin-sensitive microorganisms e.g. Staphylococci and Neisseria gonorrhoeae; asymptomatic carriers of N. meningitidis.
Dosage/Direction for Use
10 mg/kg body weight with a daily maximum dosage of 600 mg or 15 mg/kg body weight (maximum 900 mg) two or three times daily.
Administer Natricin Forte on an empty stomach. It should be taken one hour before or two hours after a meal.
Shake well the suspension before using.
Administer Natricin Forte on an empty stomach. It should be taken one hour before or two hours after a meal.
Shake well the suspension before using.
Overdosage
Do not take more than prescribed dose. Taking more medication will not improve symptoms; rather they may cause poisoning or serious side-effects. If the patient suspect who may have overdosed of Natricin Forte Suspension, go to the emergency department of the closest hospital or nursing home. Do not give medicines to other people even if they have the same condition or it seems that they may have similar conditions. Consult physician or pharmacist for more information.
Administration
Should be taken on an empty stomach: Best taken 1 hr before or 2 hr after meals.
Contraindications
Presence of jaundice; history of hypersensitivity reaction to any of the rifampicins.
Severe liver damage.
Severe liver damage.
Warnings
Rifampicin has been shown to produce liver dysfunction. Since an increased risk may exist for individuals with liver disease, benefit must be weighed carefully against any risk of further liver damage. Periodic liver function monitoring is mandatory.
Special Precautions
Liver dysfunction. Mandatory periodic liver function monitoring. May permanently discolor soft contact lenses. Do not take during the 1st 3 mth of pregnancy.
Use In Pregnancy & Lactation
Teratogenicity of rifampicin in humans has not been reported. However, rifampicin is reported to cross the placental barrier although effect of the substance on the human fetus is not known.
Before starting the treatment with Natricin, inform the doctor if the patient is pregnant or expecting pregnancy. If possible, Natricin Forte should not be taken in the first 3 months of pregnancy.
The reliability of oral contraceptives may be affected by rifampicin. Alternative contraceptive measures may be considered.
Before starting the treatment with Natricin, inform the doctor if the patient is pregnant or expecting pregnancy. If possible, Natricin Forte should not be taken in the first 3 months of pregnancy.
The reliability of oral contraceptives may be affected by rifampicin. Alternative contraceptive measures may be considered.
Adverse Reactions
Rifampicin is usually well tolerated. Adverse effects are common during intermittent therapy or after starting interrupted treatment.
Hypersensitivity reactions have been reported. Occasionally pruritus, rash, sore mouth and tongue, urticaria, and exudative conjunctivitis are manifested. Gastro-intestinal disturbances, fever and generalized numbness, allergic immunologic reactions are rare.
Administration on an empty stomach is recommended for maximal absorption, but this has to be balanced against administration after a meal to minimize gastro-intestinal intolerance.
Natricin may cause reddish discoloration of body fluids, e.g. urine, saliva and lacrimal fluid. It may permanently discolor soft contact lenses.
Natricin Forte Suspension does not contain sodium metabisulfite.
Hypersensitivity reactions have been reported. Occasionally pruritus, rash, sore mouth and tongue, urticaria, and exudative conjunctivitis are manifested. Gastro-intestinal disturbances, fever and generalized numbness, allergic immunologic reactions are rare.
Administration on an empty stomach is recommended for maximal absorption, but this has to be balanced against administration after a meal to minimize gastro-intestinal intolerance.
Natricin may cause reddish discoloration of body fluids, e.g. urine, saliva and lacrimal fluid. It may permanently discolor soft contact lenses.
Natricin Forte Suspension does not contain sodium metabisulfite.
Drug Interactions
The blood concentrations of methadone, oral hypoglycemia, digitalis derivatives, corticosteroids and anticoagulants may be affected if rifampicin is given simultaneously.
Dosage adjustment is recommended in such case.
Dosage adjustment is recommended in such case.
Storage
Store at temperatures not exceeding 30°C.
Action
Pharmacology: Pharmacodynamics: Rifampicin is bactericidal against a wide range of microorganisms and interferes with their synthesis of nucleic acids by inhibiting deoxyribonucleic acid (DNA)-dependent ribonucleic acid (RNA) polymerase. It has the ability to kill intracellular organisms.
Pharmacokinetics: Rifampicin is readily absorbed from the gastrointestinal tract. Peak serum concentrations of the order of 10 μg/ml occur about 2 to 4 hours after a dose of 10 mg/kg body weight on an empty stomach. Absorption of rifampicin is reduced when the drug is ingested with food. The pharmacokinetics (oral and intravenous) in children is similar to adults.
In normal subjects the biological half-life of rifampicin in serum averages about 3 hours after a 600 mg dose and increases to 5.1 hours after a 900 mg dose. With repeated administration, the half-life decreases and reaches average values of approximately 2-3 hours. At a dose of up to 600 mg/day, it does not differ in patients with renal failure and consequently, no dosage adjustment is required.
Pharmacokinetics: Rifampicin is readily absorbed from the gastrointestinal tract. Peak serum concentrations of the order of 10 μg/ml occur about 2 to 4 hours after a dose of 10 mg/kg body weight on an empty stomach. Absorption of rifampicin is reduced when the drug is ingested with food. The pharmacokinetics (oral and intravenous) in children is similar to adults.
In normal subjects the biological half-life of rifampicin in serum averages about 3 hours after a 600 mg dose and increases to 5.1 hours after a 900 mg dose. With repeated administration, the half-life decreases and reaches average values of approximately 2-3 hours. At a dose of up to 600 mg/day, it does not differ in patients with renal failure and consequently, no dosage adjustment is required.
MedsGo Class
Anti-TB Agents
Features
Brand
Natricin Forte
Full Details
Dosage Strength
200 mg / 5 ml
Drug Ingredients
- Rifampicin
Drug Packaging
Suspension 120ml
Generic Name
Rifampicin
Drug Flavor
Strawberry
Dosage Form
Suspension
Registration Number
DR-XY23213
Drug Classification
Prescription Drug (RX)