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Indications/Uses
Infections caused by Gram-positive and Gram-negative bacteria which respond to Amoxicillin therapy such as tonsillitis, tooth infections, pharyngitis, pneumonia and wound infections.
Dosage/Direction for Use
500 mg Capsule: 1 capsule every 8 hours. For severe infections, the dose may be doubled, or as prescribed by the physician.
250 mg/5 mL & 125 mg/5 mL Powder for Suspension: Depending on the severity of infections: 20-40 mg/kg/BW/day. Divided in 3 equal doses, to be given every 8 hours.
Usually 1-2 tsp. (5-10 mL) every 8 hours. Or as prescribed by the physician.
250 mg Capsule: 1 capsule every 8 hours or as prescribed by the physician.
100 mg/mL Powder for Suspension (Oral Drops): Infants below 6 months: 0.5-1.0 mL; 6-12 months: 1.0-1.5 mL.
Every 8 hours or as prescribed by the physician.
250 mg/5 mL & 125 mg/5 mL Powder for Suspension: Depending on the severity of infections: 20-40 mg/kg/BW/day. Divided in 3 equal doses, to be given every 8 hours.
Usually 1-2 tsp. (5-10 mL) every 8 hours. Or as prescribed by the physician.
250 mg Capsule: 1 capsule every 8 hours or as prescribed by the physician.
100 mg/mL Powder for Suspension (Oral Drops): Infants below 6 months: 0.5-1.0 mL; 6-12 months: 1.0-1.5 mL.
Every 8 hours or as prescribed by the physician.
Administration
May be taken with or without food: May be taken w/ meals for better absorption & to reduce GI discomfort.
Contraindications
Hypersensitivity to penicillin V.
Special Precautions
Contraindicated to patients who are hypersensitive to penicillin V therapy. As with other antibiotics, occasional over-growth of non-susceptible bacteria of fungi may occur. In such conditions, the drug should be discontinued and proper measures should be taken.
Adverse Reactions
Side effects, as with penicillin, are usually mild and transitory in nature, they may include diarrhea, indigestion, or occasionally rash, either urticarial (which suggest penicillin in hypersensitivity) or Erythematous. An Erythematous may be caused in patients with glandular fever, which case it is advisable to discontinue treatment.
Caution For Usage
Direction for Reconstitution: 100 mg/mL for Suspension (Oral Drops): Invert the bottle and shake to loosen the powder. To make up 10 mL, add 8 mL of water and shake well until the powder is evenly suspended. The reconstituted suspension is stable for 7 days at temperature not exceeding 30°C and, 14 days under refrigeration (2-8°C).
125 mg/5 mL Powder for Suspension: To make 60 mL reconstituted suspension, mix thoroughly the contents with 44 mL water and shake well until the powder is evenly suspended. The reconstituted suspension is stable for 7 days at room temperature not exceeding 30°C and, 14 days when refrigerated.
250 mg/5 mL Powder for Suspension: To make 60 mL reconstituted suspension, mix thoroughly the contents with 40 mL water and shake well until the powder is evenly suspended. After reconstitution, suspension retains potency for 7 days at room temperature not exceeding 30°C and, 14 days under refrigeration (2-8°C).
125 mg/5 mL Powder for Suspension: To make 60 mL reconstituted suspension, mix thoroughly the contents with 44 mL water and shake well until the powder is evenly suspended. The reconstituted suspension is stable for 7 days at room temperature not exceeding 30°C and, 14 days when refrigerated.
250 mg/5 mL Powder for Suspension: To make 60 mL reconstituted suspension, mix thoroughly the contents with 40 mL water and shake well until the powder is evenly suspended. After reconstitution, suspension retains potency for 7 days at room temperature not exceeding 30°C and, 14 days under refrigeration (2-8°C).
Storage
Store at temperatures not exceeding 30°C.
Shake well before using.
Shake well before using.
Action
Microbiology: Antibacterial: The newer semisynthetic penicillin congeners differ from the natural parent substance in many ways. In some of them the antibacterial activity is either enhanced, or actually different while in others their absorption from the gastrointestinal tract has been tremendously improved. Amoxicillin Trihydrate belong to the latter group. It is being absorbed in the gastro-intestinal tract.
Amoxicillin Trihydrate is stable in the gastric acid. It is absorbed from the gastro-intestinal tract even in the presence of food. Peak levels in the blood that are two or three times higher than those attained by equal dose of ampicillin are achieved.
Invaluable to note is the reported high concentrations of Amoxicillin in the other tissue which are not adequately reached by other antibiotics. Amoxicillin penetrates into respiratory secretions regardless of whether the mucosa is inflamed or not. Equally significant is its high urinary concentrations.
Only 20% of the drug is bound to human serum protein, giving up 80%, as free active antibiotic at the site of infections. Because of its excellent absorption from the gastro-intestinal tract, which provides high blood levels and tissue concentrations that will kill young, rapidly spreading bacteria as well as prevent the emergence of resistance strains.
Amoxicillin Trihydrate is well tolerated and less likely to cause gastro-intestinal disturbances, notably diarrhea, because it is rapidly and completely absorbed from the gastrointestinal tract. It is also devoid of the toxic effects reported with other broad spectrum antibiotic such as hepatic, renal and hematopoietic.
Amoxicillin Trihydrate in a thrice daily oral dosage (given eight hours), provides a simple dosification and the convenience of a less frequent administration. This will enable the patient to adhere to the prescribe therapy, ensuring continuous antibiotic coverage and more satisfactory therapeutic response. Amoxicillin Trihydrate is a valuable antibiotic in various infection diseases. (See table.)
Amoxicillin Trihydrate is stable in the gastric acid. It is absorbed from the gastro-intestinal tract even in the presence of food. Peak levels in the blood that are two or three times higher than those attained by equal dose of ampicillin are achieved.
Invaluable to note is the reported high concentrations of Amoxicillin in the other tissue which are not adequately reached by other antibiotics. Amoxicillin penetrates into respiratory secretions regardless of whether the mucosa is inflamed or not. Equally significant is its high urinary concentrations.
Only 20% of the drug is bound to human serum protein, giving up 80%, as free active antibiotic at the site of infections. Because of its excellent absorption from the gastro-intestinal tract, which provides high blood levels and tissue concentrations that will kill young, rapidly spreading bacteria as well as prevent the emergence of resistance strains.
Amoxicillin Trihydrate is well tolerated and less likely to cause gastro-intestinal disturbances, notably diarrhea, because it is rapidly and completely absorbed from the gastrointestinal tract. It is also devoid of the toxic effects reported with other broad spectrum antibiotic such as hepatic, renal and hematopoietic.
Amoxicillin Trihydrate in a thrice daily oral dosage (given eight hours), provides a simple dosification and the convenience of a less frequent administration. This will enable the patient to adhere to the prescribe therapy, ensuring continuous antibiotic coverage and more satisfactory therapeutic response. Amoxicillin Trihydrate is a valuable antibiotic in various infection diseases. (See table.)
MedsGo Class
Penicillins
Features
Dosage
100 mg / mL
Ingredients
- Amoxicillin
Packaging
Powder for Suspension (Oral Drops) 10ml
Generic Name
Amoxicillin Trihydrate
Registration Number
DR-XY20025
Classification
Prescription Drug (RX)
Product Questions
Questions
