KIDZ KIT 3 Syrup 120mL

Treatment of pulmonary and extrapulmonary tuberculosis. For the continuation phase (Kidz Kit 2: 4 months; Kidz Kit 3: 2 months) of short-course antituberculosis treatment.

 

Adults and Children: Kidz Kit 2: Natricin Forte: 10 mg/kg body weight. Maximum Daily Dose: 600 mg.
Curazid Forte: 10-20 mg/kg body weight. Maximum Daily Dose: 300 mg.
Kidz Kit 3: Zcure: 25 mg/kg body weight daily. Maximum Daily Dose: 3 g.
Natricin Forte: 10 mg/kg body weight. Maximum Daily Dose: 600 mg.
Curazid Forte: 10-20 mg/kg body weight. Maximum Daily Dose: 300 mg.
Administration on an empty stomach is recommended for maximal absorption, but this has to be balanced against administration after a meal to minimize GI disturbance.

Should be taken on an empty stomach. Take 1 hr before meals. May be taken w/ meals if GI discomfort occurs.

Rifampicin: Patients with jaundice or hypersensitivity to rifampicin.
Kidz Kit 3: Pyrazinamide: Patients with liver damage but if treatment is necessary, the dosage must be reduced. It should not be given to patients with acute gout or hyperuricemia.

Liver functions should be checked before treatment with rifampicin and special care should be taken in alcoholic patients or those with preexisting liver disease who require monitoring during therapy. When other liver function tests are within normal limits, hyperbilirubinemia in the 1st week or moderately elevated alkaline phosphokinase are not indications to withdraw rifampicin. However, dose adjustments are necessary when there is other evidence of more serious liver toxicity.
Isoniazid should be administered with caution to patients with convulsive disorders, a history of psychosis or hepatic or renal dysfunction. Patients who are at risk of neuropathy or pyridoxine deficiency, including those who are diabetic, alcoholic, malnourished, uremic, pregnant or HIV-infected, should receive pyridoxine usually in a dose of 10 mg daily, although some have suggested using 50 mg daily. If symptoms of hepatitis eg, malaise, fatigue, anorexia and nausea develop, isoniazid should be discontinued pending evaluation.
Periodic eye examinations during isoniazid treatment have been suggested.
Liver function should be assessed before and regularly during treatment of these antituberculosis drugs.
Kidz Kit 3: Pyrazinamide should be used with caution in patients with a history of gout. Caution should be observed in patients with impaired renal function. Increased difficulty has been reported in controlling diabetes mellitus when diabetics are given pyrazinamide.

Rifampicin is usually well tolerated. Adverse effects are more common during intermittent therapy or after restarting interrupted treatment. GI adverse effects include nausea, vomiting, anorexia and epigastric distress. Pseudomembranous colitis has been reported. Rifampicin produces transient abnormalities in liver functions. Rifampicin causes a harmless orange-red discoloration of urine and other body fluids.
Isoniazid is generally well-tolerated at currently recommended doses. Patients who are slow acetylators of isoniazid appear to have a higher incidence of some adverse effects. Also, patients whose nutrition is poor are at risk of peripheral neuritis which is one of the most common adverse effects of isoniazid. Pyridoxine may be given to prevent or treat these adverse effects. Optic neuritis has also been reported. Hematological effects reported following use of isoniazid include various anemias, agranulocytosis, thrombocytopenia and eosinophilia.
Kidz Kit 3: Hepatotoxicity is the most serious side effect of pyrazinamide therapy and its frequency appears to be dose-related. However, in its currently recommended doses, when given with isoniazid and rifampicin, the incidence of hepatitis has been reported to be <3%. Hyperuricemia commonly occurs and may lead to attacks of gout.

 

Kidz Kit 2 Other potentially hepatotoxic agents.

Storage

Anti-TB Agents