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CLARIGET Clarithromycin 500mg Film-Coated Tablet 1's

RXDRUG-DR-XY27862-1pc
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Description
lengthened at these higher doses as compared to that observed with usual doses in normal subjects. The higher plasma concentrations and longer elimination half-lives observed at these doses are consistent with the known nonlinearity in clarithromycin pharmacokinetics.
Microbiology: Clariget: Clarithromycin exerts its antibacterial action by binding to the 50S ribosomal subunits of susceptible bacteria and suppresses protein synthesis.
Clarithromycin has demonstrated excellent in vitro activity against both standard strains of bacteria and clinical isolates. It is highly potent against a wide variety of aerobic and anaerobic gram-positive and gram-negative organisms. The minimum inhibitory concentrations (MICs) of clarithromycin are generally 1 log2 dilution more potent than the MICs of erythromycin.
Clarithromycin is reported to be more active than erythromycin against susceptible streptococci and staphylococci in vitro as well as against some other species including Moraxella catarrhalis (Branhamella catarrhalis)Legionella spp, Chlamydia trachomatis and Ureaplasma urealyticum. Clarithromycin is reported to be more active than erythromycin or azithromycin against some mycobacteria including Mycobacterium avium complex and against M. leprae. It is reported to have some in vitro activity against the protozoan Toxoplasma gondii and may have some activity against cryptosporidia. The major metabolite 14-hydroxyclarithromycin is also active, and may enhance the activity of clarithromycin in vivo, notably against Haemophilus influenzae.
In vitro data also indicates that clarithromycin has excellent activity against Legionella pneumophila and Mycoplasma pneumoniae. It is bactericidal to Helicobacter pylori; this activity of clarithromycin is greater at neutral pH than at acid pH. In vitro and in vivo data show that this antibiotic has activity against clinically significant mycobacterial species.
Clariget OD: Clarithromycin has shown to be active against the following microorganisms: Aerobic Gram-positive Microorganisms: Staphylococcus aureusStreptococcus pneumoniaeStreptococcus pyogenesListeria monocytogenes.
Aerobic Gram-negative Microorganisms: Haemophilus influenzaeHaemophilus parainfluenzaeMoraxella catarrhalisNeisseria gonorrhoeaeLegionella spp (eg, Legionella pneumophila).
Anaerobes: Clostridium perfringensPeptococcus spPeptostreptococcus spPropionibacterium acnes.
Mycobacteria: Mycobacterium lepraeMycobacterium kansasiiMycobacterium chelonaeMycobacterium fortuitum, MAC (consisting of Mycobacterium aviumMycobacterium intracellulare).
Other Microorganisms: Mycoplasma pneumoniaeChlamydia pneumonia (TWAR), Chlamydia trachomatisUreaplasma urealyticum.

MedsGo Class

Macrolides

Features

Brand
Clariget
Full Details
Dosage Strength
500mg
Drug Ingredients
  • Clarithromycin
Drug Packaging
Film-Coated Tablet 1's
Generic Name
Clarithromycin
Dosage Form
Film-Coated Tablet
Registration Number
DR-XY27862
Drug Classification
Prescription Drug (RX)
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