CLARIGET Clarithromycin 500mg Film-Coated Tablet 1's
Microbiology: Clariget: Clarithromycin exerts its antibacterial action by binding to the 50S ribosomal subunits of susceptible bacteria and suppresses protein synthesis.
Clarithromycin has demonstrated excellent in vitro activity against both standard strains of bacteria and clinical isolates. It is highly potent against a wide variety of aerobic and anaerobic gram-positive and gram-negative organisms. The minimum inhibitory concentrations (MICs) of clarithromycin are generally 1 log2 dilution more potent than the MICs of erythromycin.
Clarithromycin is reported to be more active than erythromycin against susceptible streptococci and staphylococci in vitro as well as against some other species including Moraxella catarrhalis (Branhamella catarrhalis), Legionella spp, Chlamydia trachomatis and Ureaplasma urealyticum. Clarithromycin is reported to be more active than erythromycin or azithromycin against some mycobacteria including Mycobacterium avium complex and against M. leprae. It is reported to have some in vitro activity against the protozoan Toxoplasma gondii and may have some activity against cryptosporidia. The major metabolite 14-hydroxyclarithromycin is also active, and may enhance the activity of clarithromycin in vivo, notably against Haemophilus influenzae.
In vitro data also indicates that clarithromycin has excellent activity against Legionella pneumophila and Mycoplasma pneumoniae. It is bactericidal to Helicobacter pylori; this activity of clarithromycin is greater at neutral pH than at acid pH. In vitro and in vivo data show that this antibiotic has activity against clinically significant mycobacterial species.
Clariget OD: Clarithromycin has shown to be active against the following microorganisms: Aerobic Gram-positive Microorganisms: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Listeria monocytogenes.
Aerobic Gram-negative Microorganisms: Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Neisseria gonorrhoeae, Legionella spp (eg, Legionella pneumophila).
Anaerobes: Clostridium perfringens, Peptococcus sp, Peptostreptococcus sp, Propionibacterium acnes.
Mycobacteria: Mycobacterium leprae, Mycobacterium kansasii, Mycobacterium chelonae, Mycobacterium fortuitum, MAC (consisting of Mycobacterium avium, Mycobacterium intracellulare).
Other Microorganisms: Mycoplasma pneumoniae, Chlamydia pneumonia (TWAR), Chlamydia trachomatis, Ureaplasma urealyticum.
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- Clarithromycin