CIPROBAY Ciprofloxacin 2mg / mL Solution for IV Infusion 100mL

Uncomplicated and complicated infections caused by ciprofloxacin susceptible pathogens.
Infections of the respiratory tract: Ciprofloxacin can be regarded as an advisable treatment for pneumonias caused by Klebsiella spp., Enterobacter spp., Proteus spp., Escherichia coli, Pseudomonas aeruginosa, Haemophilus spp., Moraxella catarrhalis, Legionella spp., and staphylococci.
Infections of the middle ear (otitis media), of the paranasal sinuses (sinusitis), especially if these are caused by Gram-negative organisms including Pseudomonas aeruginosa or by staphylococci.
Infections of the eyes.
Infections of the kidneys and/or the efferent urinary tract.
Infections of the genital organs, including adnexitis, gonorrhea, prostatitis.
Infections of the abdominal cavity (e.g. infections of the gastrointestinal tract or of the biliary tract, peritonitis).
Infections of the skin and soft tissue Infections of the bones and joints.
Sepsis.
Infections or imminent risk of infection (prophylaxis) in patients whose immune system has been weakened (e.g. patients on immunosuppressants or have neutropenia).
Selective intestinal decontamination in immunosuppressed patients.
Prophylaxis of invasive infections due to Neisseria meningitidis.
Consideration should be given to available official guidance on the appropriate use of antibacterial agents.
Children: Ciprofloxacin may be used in children for the second- and third-line treatment of complicated urinary tract infections and pyelonephritis due to Escherichia coli (age range applied in clinical studies: 1-17 years) and for the treatment of acute pulmonary exacerbation of cystic fibrosis associated with Pseudomonas aeruginosa (age range applied in clinical studies: 5-17 years).
Treatment should only be initiated after careful benefit/risk evaluation, due to possible adverse events related to joints and/or surrounding tissues.
The clinical trials in children were performed in the indications listed previously. For other indications clinical experience is limited.
Inhalational anthrax (post-exposure) in adults and in children: To reduce the incidence or progression of disease following exposure to aerosolized Bacillus anthracis.

Ciprobay: Method of administration: Film-coated tablet: For oral use.
Ciprofloxacin (Ciprobay) film-coated tablets are to be swallowed whole with a small amount of fluid.
Ciprofloxacin (Ciprobay) film-coated tablets can be taken independently of mealtimes.
If they are taken on an empty stomach, the active substance is absorbed more rapidly. In this case, Ciprofloxacin (Ciprobay) film-coated tablets should not be taken concurrently with dairy products or with mineral-fortified drinks alone (e.g. milk, yoghurt, calcium-fortified orange juice) (see Interactions).
If the patient is unable to take Ciprofloxacin (Ciprobay) film-coated tablets because of the severity of the illness or for other reasons (e.g. patients on enteral nutrition), it is recommended to commence the therapy with an intravenous form of ciprofloxacin. After intravenous administration, the treatment can be continued orally.
Solution for infusion: For intravenous use.
Ciprofloxacin (Ciprobay) solution for infusion should be administered by intravenous infusion over a period of 60 minutes. Slow infusion into a large vein will minimize patient discomfort and reduce the risk of venous irritation. The solution for infusion can be infused either directly or after mixing with other compatible solutions for infusion.
Unless compatibility with other solutions for infusion/medicinal products has been confirmed, the solution for infusion must always be administered separately. The visual signs of incompatibility are e.g. precipitation, clouding and discoloration.
Incompatibility appears with all solutions for infusion/medicinal products that are physically or chemically unstable at the pH of the solution (e.g. penicillins, heparin solutions), especially on combination with solutions adjusted to an alkaline pH (pH of Ciprofloxacin (Ciprobay) solutions for infusion: 3.9 - 4.5). Only clear solutions are to be used.
Duration of treatment: The duration of treatment depends on the severity of the illness and on the clinical and bacteriological course. It is essential to continue therapy for at least 3 days after disappearance of the fever or of the clinical symptoms.
Mean duration of treatment: Adults: 1 day for acute uncomplicated gonorrhea and cystitis; up to 7 days for infections of the kidneys, urinary tract and abdominal cavity; over the entire period of the neutropenic phase in patients with weakened body defenses; a maximum of 2 months in osteomyelitis; and 7-14 days in all other infections.
In streptococcal infections, the treatment must last at least ten days because of the risk of late complications.
Infections caused by Chlamydia spp. should also be treated for a minimum of ten days.
Children and adolescents: Cystic Fibrosis: For acute pulmonary exacerbation of cystic fibrosis associated with Pseudomonas aeruginosa infection in pediatric patients (aged 5-17 years), the duration of treatment is 10-14 days.
Complicated Urinary Tract Infections and Pyelonephritis: For complicate urinary tract infections or pyelonephritis due to Escherichia coli, the duration of treatment is 10-21 days.
Dosage regimen: Unless otherwise prescribed, the following daily doses are recommended for: Adults: Film-coated tablet: See Table 1.

Solution for infusion: See Table 2.



Children and adolescents: Film-coated tablet: See Table 3.



Solution for infusion: See Table 4.



Missed dose: Film-coated tablet: If a dose is missed it should be taken as soon as the patient remembers and then treatment should be continued as prescribed. Double doses should not be taken to compensate for a missed dose.
Additional information on special populations: Children and adolescents: For recommended dosage regimen, see Tables 3 and 4.
Geriatric patients: Elderly patients should receive a dose as low as possible depending on the severity of their illness and the creatinine clearance (see also Patients with renal and hepatic impairment).
Patients with renal and hepatic impairment: Adults: Patients with renal impairment: Film-coated tablet: See Table 5.



Solution for infusion: See Table 6.



Patients with renal impairment on hemodialysis: Film-coated tablet: For patients with creatinine clearance between 30 and 60 mL/min/1.73 m² (moderate renal impairment) or serum creatinine concentration between 1.4 and 1.9 mg/100 mL, the maximum daily oral dose of ciprofloxacin should be 1000 mg.
For patients with creatinine clearance less than 30 mL/min/1.73 m² (severe renal impairment) or serum creatinine concentration equal or higher than 2.0 mg/100 mL, the maximum daily oral dose of ciprofloxacin should be 500 mg on dialysis days after dialysis.
Solution for infusion: For patients with creatinine clearance between 30 and 60 mL/min/1.73 m² (moderate renal impairment) or serum creatinine concentration between 1.4 and 1.9 mg/100 mL, the maximum daily intravenous dose of ciprofloxacin should be 800 mg.
For patients with creatinine clearance less than 30 mL/min/1.73 m² (severe renal impairment) or serum creatinine concentration equal or higher than 2.0 mg/100 mL, the maximum daily intravenous dose of ciprofloxacin should be 400 mg on dialysis days after dialysis.
Patients with renal impairment on continuous ambulatory peritoneal dialysis (CAPD): Film-coated tablet: The maximum daily oral dose of ciprofloxacin should be 500 mg (1 x 500 mg Ciprofloxacin (Ciprobay) film-coated tablet or 2 x 250 mg Ciprofloxacin (Ciprobay) film-coated tablets).
Solution for infusion: Addition of Ciprofloxacin (Ciprobay) solution for infusion to the dialysate (intraperitoneal): 50 mg ciprofloxacin / liter dialysate administered 4 times a day every 6 hours.
Patients with hepatic impairment: In patients with hepatic impairment, no dose adjustment is required.
Patients with renal and hepatic impairment: Film-coated tablet: For patients with creatinine clearance between 30 and 60 mL/min/1.73 m² (moderate renal impairment) or serum creatinine concentration between 1.4 and 1.9 mg/100 mL, the maximum daily oral dose of ciprofloxacin should be 1000 mg.
For patients with creatinine clearance less than 30 mL/min/1.73 m² (severe renal impairment) or serum creatinine concentration equal or higher than 2.0 mg/100 mL, the maximum daily oral dose of ciprofloxacin should be 500 mg.
Solution for infusion: For patients with creatinine clearance between 30 and 60 mL/min/1.73 m² (moderate renal impairment) or serum creatinine concentration between 1.4 and 1.9 mg/100 mL, the maximum daily intravenous dose of ciprofloxacin should be 800 mg.
For patients with creatinine clearance less than 30 mL/min/1.73 m² (severe renal impairment) or serum creatinine concentration equal or higher than 2.0 mg/100 mL, the maximum daily intravenous dose of ciprofloxacin should be 400 mg.
Children: Dosing in children with impaired renal and/or hepatic function has not been studied.

May be taken with or without food: Do not take w/ antacids, Fe or dairy products.

Hypersensitivity to ciprofloxacin or other fluoroquinolone or any of the excipients (see Excipients/Inactive Ingredients under Description),
Concurrent administration of ciprofloxacin and tizanidine (see Interactions).

Severe infections and/or infections due to Gram-positive or anaerobic bacteria: For the treatment of severe infections, staphylococcal infections and infections involving anaerobic bacteria, Ciprofloxacin (Ciprobay) should be used in combination with an appropriate antibacterial agent.
Streptococcus pneumoniae infections: Ciprofloxacin (Ciprobay) is not recommended for treatment of pneumococcal infections due to limited efficacy against Streptococcus pneumoniae.
Genital tract infections: Genital tract infections may be caused by fluoroquinolone-resistant Neisseria gonorrhoeae isolates. In genital tract infections thought or known to be due to Neisseria gonorrhoeae, it is particularly important to obtain local information on the prevalence of resistance to ciprofloxacin and to confirm susceptibility based on laboratory testing.
Cardiac disorders: Ciprofloxacin (Ciprobay) is associated with cases of QT prolongation (see Adverse Reactions). As women tend to have a longer baseline QTc interval compared with men, they may be more sensitive to QTc-prolonging medications. Elderly patients may also be more susceptible to drug-associated effects on the QT interval. Precaution should be taken when using Ciprofloxacin (Ciprobay) with concomitant drugs that can result in prolongation with the QT interval (e.g. class IA or III antiarrhythmics, tricyclic antidepressants, macrolides, antipsychotics) (see Interactions) or in patients with risk factors for QT prolongation or torsade de pointes (e.g. congenital long QT syndrome, uncorrected electrolyte imbalance such as hypokalemia or hypomagnesemia and cardiac disease such as heart failure, myocardial infarction, or bradycardia).
Children and adolescents: As with medicinal products in its class, ciprofloxacin has been shown to cause arthropathy in weight-bearing joints of immature animals (see Adverse Reactions). The analysis of available safety data from ciprofloxacin use in patients less than 18 years of age, the majority of whom had cystic fibrosis, did not disclose any evidence of drug-related cartilage or articular damage. The use of Ciprofloxacin (Ciprobay) for indications other than the treatment of acute pulmonary exacerbation of cystic fibrosis caused by Pseudomonas aeruginosa infection (children aged 5-17 years), complicated urinary tract infections and pyelonephritis due to Escherichia coli (children aged 1-17 years), and for the use in inhalational anthrax (post-exposure) was not studied. For other indications, clinical experience is limited.
Hypersensitivity: In some instances, hypersensitivity and allergic reactions may occur following a single dose (see Adverse Reactions), a physician should be informed immediately.
Anaphylactic/anaphylactoid reactions in very rare instances can progress to a life-threatening shock, in some instances after the first administration (see Adverse Reactions). In these cases, Ciprofloxacin (Ciprobay) has to be discontinued and medical treatment (e.g. treatment for shock) is required.
Gastrointestinal system: In the event of severe and persistent diarrhea during or after treatment, a physician must be consulted since this symptom can hide a serious intestinal disease (life-threatening pseudomembranous colitis with possible fatal outcome), requiring immediate treatment (see Adverse Reactions). In such cases, Ciprofloxacin (Ciprobay) must be discontinued and appropriate therapy initiated (e.g. vancomycin, orally, 4 x 250 mg/day). Medicinal products that inhibit peristalsis are contraindicated in this situation.
Hepatobiliary system: Cases of hepatic necrosis and life-threatening hepatic failure have been reported with Ciprofloxacin (Ciprobay). In the event of any signs and symptoms of hepatic disease (such as anorexia, jaundice, dark urine, pruritus, or tender abdomen), treatment should be discontinued (see Adverse Reactions).
There can be a temporary increase in transaminases, alkaline phosphatase, or cholestatic jaundice, especially in patients with previous liver damage, who are treated with Ciprofloxacin (Ciprobay) (see Adverse Reactions).
Myasthenia gravis: Ciprofloxacin (Ciprobay) should be used with caution in patients with myasthenia gravis, because symptoms can be exacerbated.
Musculoskeletal system: Ciprofloxacin (Ciprobay) should be used with caution in patients with myasthenia gravis, because symptoms can be exacerbated.
Tendinitis and tendon rupture: Tendinitis and tendon rupture (predominantly Achilles tendon), sometimes bilateral, may occur with Ciprofloxacin (Ciprobay), even within the first 48 hours of treatment. Cases occurring up to several months after completion of therapy have been reported (see Adverse Reactions). The risk of tendinopathy may be increased in elderly patients, during strenuous physical activity, in patients treated concomitantly with corticosteroids, in patients with renal impairment and patients with solid organ transplants.
At any sign of tendinitis (e.g. painful swelling, inflammation), the affected extremity should be kept at rest, any inappropriate physical exercise should be avoided, a physician should be consulted and the antibiotic treatment should be discontinued. Ciprofloxacin (Ciprobay) should be used with caution in patients with a history of tendon disorders related to fluoroquinolone treatment.
Seizures: Ciprofloxacin (Ciprobay), like other fluoroquinolones, is known to trigger seizures or lower the seizure threshold. In epileptics and patients who have suffered from previous central nervous system (CNS) disorders (e.g. lowered convulsion threshold, previous history of convulsion, reduced cerebral blood flow, altered brain structure or stroke), Ciprofloxacin (Ciprobay) should only be used where the benefits of treatment exceed the risks, since these patients are endangered because of possible undesirable CNS effects. Cases of status epilepticus have been reported (see Adverse Reactions). If seizures occur, Ciprofloxacin (Ciprobay) should be discontinued.
Psychiatric Reactions: Psychiatric reactions may occur even after the first administration of fluoroquinolones, including Ciprofloxacin (Ciprobay). In rare cases, depression or psychotic reactions can progress to suicidal ideations/thoughts and self-injurious behavior, such as attempted or completed suicide (see Adverse Reactions). In the event that the patient develops these reactions, Ciprofloxacin (Ciprobay) should be discontinued and appropriate measures instituted.
Peripheral neuropathy: Cases of sensory or sensorimotor polyneuropathy resulting in paresthesias, hypoesthesias, dysesthesias, or weakness have been reported in patients receiving fluoroquinolones including Ciprofloxacin (Ciprobay). Patients under treatment with Ciprofloxacin (Ciprobay) should be advised to inform their doctor prior to continuing treatment if symptoms of neuropathy such as pain, burning, tingling, numbness, or weakness develop (see Adverse Reactions).
Skin and appendages: Ciprofloxacin has been shown to produce photosensitivity reactions. Patients taking Ciprofloxacin (Ciprobay) should avoid direct exposure to excessive sunlight or UV-light. Therapy should be discontinued if photosensitization (i.e. sunburn-like skin reactions) occurs (see Adverse Reactions).
Cytochrome P450: Ciprofloxacin is known to be a moderate inhibitor of the CYP 450 1A2 enzymes. Care should be taken when other medicinal products are administered concomitantly which are metabolized via the same enzymatic pathway (e.g. tizanidine, theophylline, methylxantines, caffeine, duloxetine, ropinirole, clozapine, olanzapine, agomelatine). Increased plasma concentrations associated with drug-specific undesirable effects may be observed due to inhibition of their metabolic clearance by ciprofloxacin (see Interactions).
Dysglycemia: As with all fluoroquinolones, disturbances in blood glucose, including both hypoglycemia and hyperglycemia have been reported with Ciprobay. In Ciprobay-treated patients, dysglycemia occurred predominantly in elderly diabetic patients receiving concomitant treatment with an oral hypoglycemic agent (e.g. sulfonylurea) or with insulin. In diabetic patients, careful monitoring of blood glucose is recommended (see Adverse Reactions).
Injection site reaction: Solution for infusion: Local intravenous site reactions have been reported with the intravenous administration of Ciprofloxacin (Ciprobay) (see Adverse Reactions). These reactions are more frequent if the infusion time is 30 minutes or less. These may appear as local skin reactions which resolve rapidly upon completion of the infusion. Subsequent intravenous administration is not contraindicated unless the reactions recur or worsen.
Interaction with tests: Ciprofloxacin in vitro potency may interfere with the Mycobacterium tuberculosis culture test by suppression of mycobacterial growth, causing false negative results in specimens from patients currently taking Ciprofloxacin (Ciprobay).
Aortic aneurysm and dissection: Epidemiologic studies report an increased risk of aortic aneurysm and dissection after intake of fluoroquinolones, particularly in the older population.
Therefore, fluoroquinolones should only be used after careful benefit-risk assessment and after consideration of other therapeutic options in patients with positive family history of aneurysm disease, or in patients diagnosed with pre-existing aortic aneurysm and/or dissection, or in presence of other risk factors or conditions predisposing for aortic aneurysm and dissection (e.g. Marfan syndrome, vascular Ehlers-Danlos syndrome, Takayasu arteritis, giant cell arteritis, Behcet´s disease, hypertension, known atherosclerosis).
In case of sudden abdominal, chest or back pain, patients should be advised to immediately consult a physician in an emergency department.
Effects on ability to drive or use machines: Fluoroquinolones including ciprofloxacin may result in an impairment of the patient's ability to drive or operate machinery due to CNS reactions (see Adverse Reactions). This applies particularly in combination with alcohol.

Summary of the safety profile: Adverse drug reactions (ADRs) based on all clinical studies with ciprofloxacin (oral, parenteral) sorted by CIOMS III categories of frequency are listed as follows (overall n = 51621).
Tabulated list of adverse reactions: The frequencies of ADRs reported with Ciprofloxacin (Ciprobay) are summarized in the following table. Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.
Frequencies are defined as: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000).
The ADRs identified only during post marketing surveillance, and for which a frequency could not be estimated, are listed under 'not known'. (See Table 7.)



In isolated instances, some serious adverse drug reactions may be long-lasting (> 30 days) and disabling; such as tendinitis, tendon rupture, musculoskeletal disorders, and other reactions affecting the nervous system including psychiatric disorders and disturbance of senses.
The following undesirable effects have a higher frequency category in the subgroups of patients receiving intravenous or sequential (intravenous to oral) treatment: See Table 8.



The MedDRA preferred term is used to describe a certain reaction and its synonyms and related conditions. ADR term representation is based on MedDRA version 14.0 (except for 'Mycotic Superinfections' and 'Unspecific Pain').
Additional information on special populations: Pediatric population: The incidence of arthropathy (arthralgia, arthritis), mentioned previously, is referring to data collected in studies with adults. In children, arthropathy is reported to occur commonly (see Precautions).

Drugs known to prolong QT interval: Ciprofloxacin (Ciprobay), like other fluoroquinolones, should be used with caution in patients receiving drugs known to prolong the QT interval (e.g. Class IA and III anti-arrhythmics, tricyclic antidepressants, macrolides, antipsychotics) (see Precautions).
Probenecid: Probenecid interferes with renal secretion of ciprofloxacin. Co-administration of probenecid containing medicinal products and Ciprofloxacin (Ciprobay) increases the ciprofloxacin serum concentrations.
Tizanidine: In a clinical study in healthy subjects, there was an increase in tizanidine serum concentrations (C_max increase: 7-fold, range: 4 to 21-fold; AUC increase: 10-fold, range: 6 to 24-fold) when given concomitantly with ciprofloxacin. Associated with the increased serum concentrations was a potentiated hypotensive and sedative effect (see Cytochrome P450 under Precautions). Tizanidine containing medicinal products must not be administered together with Ciprofloxacin (Ciprobay) (see Contraindications).
Theophylline: Concurrent administration of ciprofloxacin and theophylline containing medicinal products can cause an undesirable increase in the serum theophylline concentration. This can lead to theophylline-induced undesirable effects. In very rare cases, these undesirable effects can be life threatening or fatal.
If concurrent use of the two medicinal products is unavoidable, the serum theophylline concentration should therefore be checked and the theophylline dose appropriately reduced (see Cytochrome P450 under Precautions).
Other xanthine derivatives: On concurrent administration of ciprofloxacin and caffeine or pentoxifylline (oxpentifylline) containing products, raised serum concentrations of these xanthine derivatives were reported.
Phenytoin: Altered (decreased or increased) serum levels of phenytoin were observed in patients receiving Ciprofloxacin (Ciprobay) and phenytoin simultaneously. To avoid the loss of seizure control associated with decreased phenytoin levels, and to prevent phenytoin overdose-related undesirable effects when Ciprofloxacin (Ciprobay) is discontinued in patients receiving both agents, monitoring of phenytoin therapy, including phenytoin serum concentration measurements, is recommended during and shortly after co-administration of Ciprofloxacin (Ciprobay) with phenytoin.
Methotrexate: Renal tubular transport of methotrexate may be inhibited by concomitant administration of Ciprofloxacin (Ciprobay), potentially leading to increased plasma levels of methotrexate. This might increase the risk of methotrexate-associated toxic reactions. Therefore, patients under methotrexate therapy should be carefully monitored when concomitant Ciprofloxacin (Ciprobay) therapy is indicated.
NSAID: Animal studies have shown that the combination of very high doses of quinolones (gyrase inhibitors) and certain non-steroidal anti-inflammatory agents (but not acetylsalicylic acid) can provoke convulsions.
Cyclosporin: A transient rise in the concentration of serum creatinine was observed when ciprofloxacin and cyclosporin containing medicinal products were administered simultaneously. Therefore, it is frequently (twice a week) necessary to control the serum creatinine concentrations in these patients.
Vitamin K antagonists: Simultaneous administration of Ciprofloxacin (Ciprobay) with a vitamin K antagonist may augment its anticoagulant effects. The risk may vary with the underlying infection, age and general status of the patient so that the contribution of ciprofloxacin to the increase in INR (international normalized ratio) is difficult to assess. The INR should be monitored frequently during and shortly after co-administration of Ciprofloxacin (Ciprobay) with a vitamin K antagonist (e.g. warfarin, acenocoumarol, phenprocoumon, or fluindione).
Duloxetine: In clinical studies, it was demonstrated that concomitant use of duloxetine with strong inhibitors of the CYP450 1A2 isozyme such as fluvoxamine, may result in an increase of AUC and C_max of duloxetine. Although no clinical data are available on a possible interaction with ciprofloxacin, similar effects can be expected upon concomitant administration (see Cytochrome P450 under Precautions).
Ropinirole: It was shown in a clinical study that concomitant use of ropinirole with ciprofloxacin, a moderate inhibitor of the CYP450 1A2 isozyme, results in an increase of C_max and AUC of ropinirole by 60% and 84%, respectively. Monitoring ropinirole-related undesirable effects, dose adjustment as appropriate is recommended during and shortly after co-administration with Ciprofloxacin (Ciprobay) (see Cytochrome P450 under Precautions).
Lidocaine: It was demonstrated in healthy subjects that concomitant use of lidocaine containing medicinal products with ciprofloxacin, a moderate inhibitor of CYP450 1A2 isozyme, reduces clearance of intravenous lidocaine by 22%. Although lidocaine treatment was well tolerated, a possible interaction with ciprofloxacin associated with side effects may occur upon concomitant administration.
Clozapine: Following concomitant administration of 250 mg ciprofloxacin with clozapine for 7 days, serum concentrations of clozapine and N-desmethylclozapine were increased by 29% and 31%, respectively. Clinical surveillance and appropriate adjustment of clozapine dosage during and shortly after co-administration with Ciprofloxacin (Ciprobay) are advised (see Cytochrome P450 under Precautions).
Sildenafil: C_max and AUC of sildenafil were increased approximately twofold in healthy subjects after an oral dose of 50 mg given concomitantly with 500 mg ciprofloxacin. Therefore, caution should be used prescribing Ciprofloxacin (Ciprobay) concomitantly with sildenafil taking into consideration the risks and the benefits.
Agomelatine: In clinical studies, it was demonstrated that fluvoxamine, as a strong inhibitor of the CYP450 1A2 isoenzyme, markedly inhibits the metabolism of agomelatine resulting in a 60-fold increase of agomelatine exposure. Although no clinical data are available for a possible interaction with ciprofloxacin, a moderate inhibitor of CYP450 1A2, similar effects can be expected upon concomitant administration (see Cytochrome P450 under Precautions).
Zolpidem: Co-administration of ciprofloxacin may increase blood levels of zolpidem, concurrent use is not recommended.
Film-coated tablet: Chelation complex formation: The simultaneous administration of Ciprofloxacin (Ciprobay) and multivalent cation-containing medicinal products and mineral supplements (e.g. calcium, magnesium, aluminum, iron), polymeric phosphate binders (e.g. sevelamer, lanthanum carbonate), sucralfate or antacids, and highly buffered drugs (e.g. didanosine tablets) containing magnesium, aluminum, or calcium reduce the absorption of ciprofloxacin. Consequently, Ciprofloxacin (Ciprobay) should be administered either 1-2 hours before or at least 4 hours after these preparations.
The restriction does not apply to antacids belonging to the class of H₂ receptor blockers.
Food and dairy products: The concurrent administration of dairy products or mineral-fortified drinks alone (e.g. milk, yoghurt, calcium-fortified orange juice) and Ciprofloxacin (Ciprobay) should be avoided because absorption of ciprofloxacin may be reduced. Dietary calcium as part of a meal, however, does not significantly affect absorption.
Metoclopramide: Metoclopramide accelerates the absorption of ciprofloxacin resulting in a shorter time to reach maximum plasma concentrations. No effect was seen on the bioavailability of ciprofloxacin.
Omeprazole: Concomitant administration of ciprofloxacin and omeprazole containing medicinal products results in a slight reduction of C_max and AUC of ciprofloxacin.

Quinolones