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AXET Cefuroxime AXETil 500mg Film-Coated Tablet 1's

RXDRUG-DRP-560-01-1pc
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Description

Indications/Uses

Cefuroxime axetil is a 2nd generation cephalosporin antibiotic used in the treatment of susceptible infections. These have included bone and joint infections, bronchitis (and other lower respiratory tract infections), gonorrhea, meningitis, otitis media, peritonitis, pharyngitis, sinusitis, skin infections (including soft tissue infections) and urinary tract infections. It is also used for surgical infection prophylaxis.
 

Dosage/Direction for Use

Usual oral dose for adults is 125 mg twice daily for uncomplicated urinary tract infections and 250-500 mg twice daily for respiratory tract infections.
 

Administration

Should be taken with food.
 

Contraindications

Patients who are hypersensitive to cefuroxime or to other cephalosporins.
 

Special Precautions

Care is necessary in patients with a history of allergy.
 

Adverse Reactions

GI disturbances, including diarrhea, nausea and vomiting have occurred in some patients receiving cefuroxime axetil. There have been rare reports of erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis.
 

Drug Interactions

Probenecid reduces the renal clearance of cefuroxime.
 

Storage

Store at temperatures not exceeding 30°C.
 

Action

Antibacterial.
Pharmacology: Pharmacokinetics: Cefuroxime axetil is absorbed from the GIT and is rapidly hydrolyzed in the intestinal mucosa and blood to cefuroxime. Absorption is enhanced in the presence of food. Peak plasma concentrations are reported about 2-3 hrs after an oral dose. It is widely distributed in the body including pleural fluid, sputum, synovial fluid and aqueous humor, but only achieves therapeutic concentrations in the CSF when the meninges are inflamed. It crosses the placenta and has been detected in breast milk. It is excreted unchanged by glomerular filtration and renal tubular secretion and high concentrations are achieved in the urine.
 

MedsGo Class

Cephalosporins

Features

Brand
Axet
Full Details
Dosage Strength
500 mg
Drug Ingredients
  • Cefuroxime
Drug Packaging
Film-Coated Tablet 1's
Generic Name
Cefuroxime Axetil
Dosage Form
Film-Coated Tablet
Registration Number
DRP-560-01
Drug Classification
Prescription Drug (RX)
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