ANPHECLOR Chloramphenicol Palmitate 125mg / 5mL Suspension 60mL 1's
RXDRUG-DR-XY17765
Discreet Packaging
FDA-registered Products
FDA-licensed Pharmacies
Indications/Uses
Rickettsial infections, typhoid fever, & severe infections due to moderately resistant organisms.
Typhoid fever, meningitis, brain abscesses, rickettsial infections & other diseases which do not respond to other standard antimicrobial agent.
Dosage/Direction for Use
Adult & childn 50 mg/kg in divided doses every 6 hr, up to 100 mg/kg in severe infections due to moderately resistant organisms. Duration of treatment: Rickettsial diseases Continue for 4 days after temp is normal; typhoid fever 8-10 days. Full-term infant >2 wk Up to 50 mg/kg daily in 4 divided doses. Premature & full-term neonate 25 mg/kg daily.
Doses are expressed in terms of Chloramphenicol base and are similar whether administered by mouth or intravenously. For adults and children, the usual dose is 50 mg per kg body weight daily in divided doses every 6 hours up to 100 mg per kg body-weight daily may be given in severe infections due to moderately resistant organisms, although these higher doses should be reduced as soon as possible. To minimized the risk of relapse, it has been recommended that treatment should be continued for 4 days after the patients' temperature has returned to normal in rickettsial diseases and for 8 to 10 days in typhoid fever. In cases of severe infection, premature and full term neonates may be given daily doses of 25 mg per kg body weight and full-terms infants over the age of 2 weeks may be given up to 50 mg per kg daily, in 4 divided doses. However, Chloramphenicol (Anpheclor) should only be used when there is no other suitable treatment for the severe infections and when concentrations can be monitored.
In patients with impaired hepatic function or severe renal failure, the dose of Chloramphenicol (Anpheclor) may need to be reduced because of decreased metabolism or excretion of Chloramphenicol (Anpheclor).
In patients with impaired hepatic function or severe renal failure, the dose of Chloramphenicol (Anpheclor) may need to be reduced because of decreased metabolism or excretion of Chloramphenicol (Anpheclor).
Administration
Should be taken on an empty stomach: Take 1 hr before or 2 hr after meals.
Contraindications
History of hypersensitivity or toxic reaction. Minor infection, prophylaxis.
Warnings
For additional cautionary notes to warn of the potential risk of using the medicine.
Serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia, thrombocytopenia and granulocytopenia) are known to occur after the administration of chloramphenicol.
Special Precautions
Serious & fatal blood dyscrasias (aplastic & hypoplastic anemia, thrombocytopenia & granulocytopenia). Impaired hepatic or severe renal failure (reduce dose). Avoid repeated courses & prolonged treatment. Perform periodic blood exams. Avoid concomitant administration w/ other drugs liable to depress bone marrow function. Pregnancy & lactation. Risk of grey syndrome in newborn infants.
Chloramphenicol (Ampheclor) is contraindicated in patients with a history of hypersensitivity or toxic reaction to the drug. It should never be given for minor infections or for prophylaxis. Repeated courses and prolonged treatment should be avoided. Routine periodic Blood examinations are advisable in all patients, but will not warm of aplastic anemia.
Because of the risk of the grey syndrome, newborn infants should never be given Chloramphenicol (Anpheclor). Unless it may be life saving and there is no alternative treatment. The use of chloramphenicol (Anpheclor) is probably best avoided during pregnancy and in nursing mothers since chloramphenicol (Anpheclor) given to the mother is excreted in the milk.
Concomitant administration of chloramphenicol with other drugs liable to depress bone marrow function should be avoided.
Because of the risk of the grey syndrome, newborn infants should never be given Chloramphenicol (Anpheclor). Unless it may be life saving and there is no alternative treatment. The use of chloramphenicol (Anpheclor) is probably best avoided during pregnancy and in nursing mothers since chloramphenicol (Anpheclor) given to the mother is excreted in the milk.
Concomitant administration of chloramphenicol with other drugs liable to depress bone marrow function should be avoided.
Adverse Reactions
Bone marrow depression, aplastic anemia, hemolytic anemia, hypersensitivity reaction; GI symptoms including nausea, vomiting & diarrhea; stomatitis, glossitis & rectal irritation.
Chloramphenicol (Anpheclor) may cause serious and sometimes fatal adverse effects such as depression of the bone marrow, aplastic anemia, hemolytic anemia, hypersensitivity reaction may occur especially after topical use. Gastro-intestinal symptoms including nausea, vomiting, and diarrhea can follow oral administration. Disturbances of the oral and intestinal flora may cause stomatitis, glossitis, and rectal irritation.
Storage
Store at temperature not exceeding 30°C.
Action
Each 5 mL contains: Chloramphenicol (as palmitate) 125 mg.
MedsGo Class
Chloramphenicols
Features
Brand
Anpheclor
Full Details
Dosage Strength
125 mg / 5 ml
Drug Ingredients
- Chloramphenicol
Drug Packaging
Suspension 60ml
Generic Name
Chloramphenicol
Dosage Form
Suspension
Registration Number
DR-XY17765
Drug Classification
Prescription Drug (RX)
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