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Indications/Uses
Paracetamol is given by intravenous infusion for the short-term treatment of moderate pain, particularly after surgery, and of fever.
Dosage/Direction for Use
Paracetamol is given by intravenous infusion over 15 minutes; dosage may be calculated by weight as follows: Patients weighing over 50 kg: single doses of 1 gram every 4 or more hours to a maximum of 4 grams daily.
From 33 kg to 50 kg: single doses of 15 mg/kg every 4 or more hours, to a maximum of 60 mg/kg or 3 grams daily, whichever is less.
From 33 kg to 50 kg: single doses of 15 mg/kg every 4 or more hours, to a maximum of 60 mg/kg or 3 grams daily, whichever is less.
Overdosage
Overdosage with paracetamol can result in severe liver damage and sometimes acute renal tubular necrosis. Prompt treatment with acetylcysteine or methionine is essential.
Special Precautions
Paracetamol should be given with care to patients with impaired kidney or liver function. It should also be given with care to patients with alcohol dependence.
Adverse Reactions
Adverse effects of paracetamol are rare and usually mild, although haematological reactions including thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Skin rashes and other hypersensitivity reactions occur occasionally. Hypotension has been reported rarely with parenteral use.
Drug Interactions
The risk of Paracetamol toxicity may be increased in patients receiving other potentially hepatotoxic drugs or drugs that induce liver microsomal enzymes. The absorption of paracetamol may be accelerated by drugs such as metoclopramide. Excretion may be affected and plasma concentrations altered when given with probenecid. Colestyramine reduces the absorption of paracetamol if given within 1 hour of paracetamol.
Storage
Store at temperatures not exceeding 30°C. Protect from light. Do not freeze.
Action
Pharmacology: Pharmacokinetics: Paracetamol is readily absorbed from the gastrointestinal tract with peak plasma concentrations occurring about 10 to 60 minutes after oral doses. Paracetamol is distributed into most body tissues. It crosses the placenta and is present in breast milk. Plasma-protein binding is negligible at usual therapeutic concentrations but increases with increasing concentrations. The elimination half-life of paracetamol varies from about 1 to 3 hours. Paracetamol is metabolised mainly in the liver and excreted in the urine mainly as the glucuronide and sulfate conjugates. Less than 5% is excreted as unchanged paracetamol. A minor hydroxylated metabolite (N-acetyl-p-benzoquinoneimine), is usually produced in very small amounts by cytochrome P450 isoenzymes (mainly CYP2E1 and CYP3A4) in the liver and kidney. It is usually detoxified by conjugation with glutathione but may accumulate after paracetamol overdosage and cause tissue damage.
MedsGo Class
Analgesics (Non-Opioid) & Antipyretics
Features
Brand
Pyrex
Full Details
Dosage Strength
10 mg / ml (1g / 100 ml)
Drug Ingredients
- Paracetamol
Drug Packaging
Solution for Infusion (I.V.) 100ml
Generic Name
Paracetamol
Dosage Form
Solution for Infusion (I.V.)
Registration Number
DR-XY46688
Drug Classification
Prescription Drug (RX)