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Indications/Uses
Mefenamic Acid is indicated in the relief of mild to moderately severe somatic and neuritic pains such as headache, migraine, traumatic pain, postpartum pain, postoperative pain, dental pain and pain conditions: dysmenorrheal, hemorralgia, accompanied by spasm or hypogastric pain.
Dosage/Direction for Use
Tab 500 mg: One tablet three times a day preferably taken with food. Or as prescribed by the physician.
Cap 250 mg & 500 mg: One to two capsules three times a day or as prescribed by the physician.
50 mg/5 mL suspension: Children: 6 months to under 2 years: 5 mL (1 teaspoonful).
2 years to under 5 years: 10 mL (2 teaspoonfuls).
5 years to under 9 years: 15 mL (3 teaspoonfuls).
9 years to 12 years: 20 mL (4 teaspoonfuls) repeated as necessary up to three times daily or as prescribed by the physician. Should not be given for longer than 7 days at a time.
Cap 250 mg & 500 mg: One to two capsules three times a day or as prescribed by the physician.
50 mg/5 mL suspension: Children: 6 months to under 2 years: 5 mL (1 teaspoonful).
2 years to under 5 years: 10 mL (2 teaspoonfuls).
5 years to under 9 years: 15 mL (3 teaspoonfuls).
9 years to 12 years: 20 mL (4 teaspoonfuls) repeated as necessary up to three times daily or as prescribed by the physician. Should not be given for longer than 7 days at a time.
Overdosage
Although doses up to 6000 mg/day have been given no specific information is available on the management of acute massive overdosage.
Should accident overdosage occur, the stomach should be emptied by inducing emesis or by careful gastric lavage followed by the administration of activated charcoal.
Should accident overdosage occur, the stomach should be emptied by inducing emesis or by careful gastric lavage followed by the administration of activated charcoal.
Administration
Should be taken with food: Take immediately after meals.
Contraindications
Mefenamic Acid is contraindicated in inflammatory bowel disease and in patients suffering from peptic and intestinal ulceration and in patients with renal or hepatic impairment.
Warnings
Absolute contraindications: Not be given to those patients who have history of: Stroke: cerebrovascular accident, CVA; Heart attack: Myocardial infarction, MI; Coronary artery bypass graft: CABG; Uncontrolled hypertension; Congestive heart failure (CHF) NYHA II-IV.
Contraindication in patients with history of hypersensitivity to ASA or any other NSAIDs.
NSAIDs are contraindicated in patients with previous or active peptic ulceration.
Use with caution in patients with cardiac, liver and renal disease. Dose adjustment like using the lowest effective dose and monitoring of renal and liver functions should be instituted.
Contraindication in patients with history of hypersensitivity to ASA or any other NSAIDs.
NSAIDs are contraindicated in patients with previous or active peptic ulceration.
Use with caution in patients with cardiac, liver and renal disease. Dose adjustment like using the lowest effective dose and monitoring of renal and liver functions should be instituted.
Special Precautions
In patients suffering from dehydration and renal disease, particularly the elderly, concurrent therapy with other plasma protein binding drugs may decessitate a modification in dosage. In the case of anticoagulants, the dose of the anticoagulant may need to be reduced. The safety of Mefenamic Acid in pregnancy and in children under 14 years of age has not been established.
Use In Pregnancy & Lactation
Pregnancy: Congenital abnormalities have been reported in association with NSAID administration in man; however, these are low in frequency and do not appear to follow any discernible pattern. In view of the known effects of NSAIDs on the fetal cardiovascular system (risk of closure of the ductus arteriosus), use in the last trimester of pregnancy is contraindicated. The onset of labor may be delayed and the duration increased with an increased bleeding tendency in both mother and child. NSAIDs should not be used during first trimesters of pregnancy or labor unless the potential benefit to the patient outweighs the potential risk to the fetus.
Lactation: Trace amounts of mefenamic acid may be present in breast milk and transmitted to the nursing infant. Therefore, mefenamic acid should not be taken by nursing mothers.
Lactation: Trace amounts of mefenamic acid may be present in breast milk and transmitted to the nursing infant. Therefore, mefenamic acid should not be taken by nursing mothers.
Adverse Reactions
Gastrointestinal discomfort, diarrhea or gas constipation, nausea, vomiting, drowsiness and dizziness have been observed. Signs of hemolytic anemia should be watched in cases when the drug is taken on prolonged period of time. As in all inhibitors of prostaglandin synthesis, Mefenamic Acid can affect platelet function. In large doses the drug may induce Grand Mal convulsions hence it is suggested to avoid this in epileptics.
Drug Interactions
Concomitant therapy with other plasma protein binding drugs may necessitate a modification of dosage. In the case of anticoagulants frequent monitoring of prothrombin time is necessary.
Storage
Store at temperatures not exceeding 30°C.
Action
Pharmacology: Mefenamic Acid is a unique analgesic with dual action. It inhibits prostaglandin synthesis and blocks its action at the receptor site.
MedsGo Class
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Features
Brand
Ponser
Full Details
Dosage Strength
50mg / 5ml
Drug Ingredients
- Mefenamic Acid
Drug Packaging
Suspension 60ml
Generic Name
Mefenamic Acid
Dosage Form
Suspension
Registration Number
DR-XY24412
Drug Classification
Prescription Drug (RX)