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Indications/Uses
Pyrexia of unknown origin and for symptomatic relief of fever and pain associated with common childhood disorders, tonsillitis, upper respiratory tract infections, post immunization reactions, after tonsillectomy and other conditions where patient is unable to take oral medications but where Paracetamol can be administered with advantage. For prevention of febrile convulsion.
Dosage/Direction for Use
Adults and children 10 years and above: 2-3 mL.
Children up to 10 years: 1-2 mL.
Infants: ½ mL.
Depending on severity of case, dose may be repeated 4 hourly till temperature returns to normal or as prescribed by the physician. In severe cases, dose may be administered intravenously very slowly.
Children up to 10 years: 1-2 mL.
Infants: ½ mL.
Depending on severity of case, dose may be repeated 4 hourly till temperature returns to normal or as prescribed by the physician. In severe cases, dose may be administered intravenously very slowly.
Overdosage
Symptoms: Symptoms of overdosage may include nausea, vomiting, abdominal pain, diaphoresis, generalized weakness and lethargy. If an overdosage of Paracetamol is suspected, blood should b withdrawn immediately for Paracetamol plasma assay, without regard to the presence or absence of symptoms.
Treatment: The acute hepatotoxicity and nephrotoxicity of Paracetamol can be overcome by the administration of sulphydryl donors eg, N-acetylcysteine which should be given as soon as possible after ingestion. Treatment after 12 hours is not effective.
Paracetamol overdosage should be treated with gastric lavage if the patients is seen within 24 hours of ingestion of the drug.
Treatment: The acute hepatotoxicity and nephrotoxicity of Paracetamol can be overcome by the administration of sulphydryl donors eg, N-acetylcysteine which should be given as soon as possible after ingestion. Treatment after 12 hours is not effective.
Paracetamol overdosage should be treated with gastric lavage if the patients is seen within 24 hours of ingestion of the drug.
Contraindications
Nephropathy.
Special Precautions
Paracetamol should be given with care to patients with impaired kidney or liver function. Not to be given to neonates.
Adverse Reactions
Paracetamol has rarely been found to produce any side effects in therapeutic doses and is usually well tolerated by aspirin sensitive patients. Toxicity may result from a single toxic dose of the drug or from chronic ingestion.
The following adverse reactions have been reported: Skin eruption, haematological toxicity eg, thrombocytopenia and leucopenia, methaemoglobinaemia which can result in cyanosis, and on long-term use, renal damage can result.
The following adverse reactions have been reported: Skin eruption, haematological toxicity eg, thrombocytopenia and leucopenia, methaemoglobinaemia which can result in cyanosis, and on long-term use, renal damage can result.
Storage
Store at temperatures not exceeding 30°C.
Action
Antipyretic and analgesic.
Pharmacology: Paracetamol produces analgesia by raising the threshold of the pain center in the brain and by obstructing impulses at the pain mediating chemoreceptors.
The drug produces antipyresis by an action on the hypothalamus; heat dissipation is increased as a result of vasodilation and increased peripheral blood flow.
Pharmacokinetics: Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract. Following oral administration, peak plasma levels are attained in 10 min-1 hr and the half-life is 75 min-3 hrs.
Distribution of Paracetamol to most body tissues and fluids is both rapid and uniform.
Paracetamol is excreted in the urine primarily as the glucoronide and smaller amounts as the sulphate, mercapturate and unchanged drug. Approximately 85% of a dose of Paracetamol is excreted in the urine within 24 hours after administration.
Pharmacology: Paracetamol produces analgesia by raising the threshold of the pain center in the brain and by obstructing impulses at the pain mediating chemoreceptors.
The drug produces antipyresis by an action on the hypothalamus; heat dissipation is increased as a result of vasodilation and increased peripheral blood flow.
Pharmacokinetics: Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract. Following oral administration, peak plasma levels are attained in 10 min-1 hr and the half-life is 75 min-3 hrs.
Distribution of Paracetamol to most body tissues and fluids is both rapid and uniform.
Paracetamol is excreted in the urine primarily as the glucoronide and smaller amounts as the sulphate, mercapturate and unchanged drug. Approximately 85% of a dose of Paracetamol is excreted in the urine within 24 hours after administration.
MedsGo Class
Analgesics (Non-Opioid) & Antipyretics
Features
Dosage
150 mg / ml
Ingredients
- Paracetamol
Packaging
Solution for Injection (I.M./I.V.) 10's
Generic Name
Paracetamol
Registration Number
DR-XY19474
Classification
Prescription Drug (RX)
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