SOFINOX Sodium Fusidate 2.0% Cream 5g
RXDRUG-DRP-4092
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Features
Brand
Sofinox
Full Details
Dosage Strength
20mg /g (2%w/w)
Drug Ingredients
- Fusidate
Drug Packaging
Cream 5g
Generic Name
Sodium Fusidate
Dosage Form
Cream
Registration Number
DRP-4092
Drug Classification
Prescription Drug (RX)
Description
Indications/Uses
Indicated for the treatment of skin infection caused by Staphylococci, Streptococci, Corynebacterium minutissimum, and other organisms sensitive to Sodium Fusidate such as impetigo and secondary infections (infections that develop after skin has been injured) to burns or broken skin.
Dosage/Direction for Use
Sodium Fusidate (Sofinox) cream is applied to the affected area 2-3 times daily, generally for a period of 7 days.
Storage
Store at temperatures not exceeding 30°C. Do not freeze.
Action
Pharmacology: Sodium fusidate, an antibiotic derived from Fusidium coccineum, exerts powerful antibacterial activity against a number of gram-positive organisms. Staphylococci, including the strains resistant to penicillin or other antibiotics, are particularly susceptible to sodium fusidate.
The therapeutic efficacy of topically applied sodium fusidate is due partly to pronounced antibacterial activity of sodium fusidate against the organisms responsible for skin infection, and partly to the unique ability of this antibiotic to penetrate intact skin.
Pharmacodynamics: Fusidic acid disrupts translocation of peptide subunits and elongating the peptide chain of susceptible bacteria, thus inhibiting protein synthesis. The Chitosan demonstrates blood clotting, film forming, wound healing and skin restoration properties.
Pharmacokinetics: Fusidate is widely distributed into tissues and body fluids. It has been found in the fetal circulation and in breast milk. About 95% or more of fusidate in the circulation is bound to plasma proteins. Fusidate has a plasma half-life of about 10 to 15 hours. It is excreted in the bile, almost entirely as metabolites, some of which have weak antimicrobial activity. About 2% appears unchanged in the faeces. Little is excreted in the urine or removed by haemodialysis.
The therapeutic efficacy of topically applied sodium fusidate is due partly to pronounced antibacterial activity of sodium fusidate against the organisms responsible for skin infection, and partly to the unique ability of this antibiotic to penetrate intact skin.
Pharmacodynamics: Fusidic acid disrupts translocation of peptide subunits and elongating the peptide chain of susceptible bacteria, thus inhibiting protein synthesis. The Chitosan demonstrates blood clotting, film forming, wound healing and skin restoration properties.
Pharmacokinetics: Fusidate is widely distributed into tissues and body fluids. It has been found in the fetal circulation and in breast milk. About 95% or more of fusidate in the circulation is bound to plasma proteins. Fusidate has a plasma half-life of about 10 to 15 hours. It is excreted in the bile, almost entirely as metabolites, some of which have weak antimicrobial activity. About 2% appears unchanged in the faeces. Little is excreted in the urine or removed by haemodialysis.
MedsGo Class
Topical Antibiotics
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