Godex DS Carnitine Orotate / Hepatic Extract Antitoxic Fraction / Adenine Hydrochloride / Pyridoxine Hydrochloride / Riboflavin / Cyanocobalamin Capsule 1's

Caution During Administration: Follow recommended dosage and administration method and physician's instructions for administration.
Caution During and After Administration of Godex DS: If there is any specific symptom following administration, discontinue usage and consult the physician.
Consult the physician if there is no improvement after 1 month of treatment.
Godex DS is hygroscopic, therefore be cautious on storing after opening the case.

 

Store at temperatures not exceeding 30°C. Avoid exposure to sunlight. Keep cool and dry.

 

Pharmacology: Carnitine orotate is nonhygroscopic (does not absorb/adsorb water from the surrounding environment), less deliquescent (does not readily liquefy when exposed to air) and is more soluble in water relative to the extremely hygroscopic L-carnitine. The ionic complex salt has the property of supplying the body with orotic acid and carnitine.
In effect, in order to exert its anti-mitochondrial dysfunction properties facilitating the synthesis of proteins, orotic acid has to be saltified with an organic cation eg, carnitine, for its total solubilization and subsequent ease of absorption.
On the other hand, carnitine not only prevents and checks the tendency of orotic acid to the fatty deposit in the liver, but also facilitates the degradation and elimination of the existing fatty deposits.
The orotic component is the base substance of pyrimidine nucleotides, which in turn change into nucleotides and these into uridine triphosphate (UTP), adenosine triphosphate (ATP), up to the final synthesis of proteins.
The carnitine component intervenes in the transport oxidation of fatty acids, acting as a lipotropic and an antilipemic factor in the body.
Adenine is main component of ATP, which activates methionine, a necessary condition for the later to give the methylic groups used in the reactions of transmethylation.
Pyridoxine acts in the process of decarboxylation of serine, changing it into ethanolamine in the process of synthesis of choline.
Cyanocobalamin, intervenes in the reduction of a format in the methyl group, that changes UTP into TTP, it also activates the enzymes intervening in the oxidation of choline into betaine.
Hepatic extract antitoxic fraction is specifically hydrolyzed 17 amino acid complex, which is prepared by enzymatic hydrolysis from the bovine liver in order to ensure bioefficiency of its detoxifying effects.
Pharmacokinetics: General: Godex DS peak plasma concentrations are observed about 30 min after dosing.
Adenosine IV is rapidly cleared from the circulation via cellular uptake, primarily by erythrocytes and vascular endothelial cells. The process involves a specific transmembrane nucleoside carrier system that is reversible, nonconcentrative and bidirectionally symmetrical. Intracellular adenosine is rapidly metabolized either via phosphorylation to adenosine monophosphate by adenosine kinase or via deamination to inosine by adenosine deaminase in the cytosol.
Pyridoxine HCl (vitamin B₆) is readily absorbed from the gastrointestinal tract, mainly in the jejunum and is converted to pyridoxal phosphate which is totally bound to plasma proteins.
Hepatic extract antitoxic fraction is a specifically hydrolyzed 17 amino acid complex, which is prepared by enzymatic hydrolysis from the liver and readily absorbed from the gastrointestinal tract.
Metabolism and Elimination: Godex DS is predominantly metabolized in the liver.
Carnitine orotate is metabolized in the liver which when metabolized leaves free its carnitine content. A different behavior was observed in the elimination of exogenous carnitine via urine. In animal experiment, the elimination of carnitine was rapid and proportional to the dose of carnitine orotate. While in man, the moderate ingestion of carnitine orotate does not produce an increase carnitine elimination in the urine, the retention of carnitine in the body tissues means a better utilization of the substance in the body.
Adenosine has a very short t½. In human blood, its t½ is <10 sec. There are 2 important metabolic fates for adenosine. Most importantly, adenosine is rapidly transported into red blood cells (and other cell types) where it is rapidly deaminated by adenosine deaminase to inosine, which is further broken down to hypoxanthine, xanthine and uric acid, which is excreted by the kidneys.
Adenosine can be acted on by adenosine kinase and rephosphorylated to adenosine monophosphate (AMP). The salvage pathway helps maintain the adenine nucleotide pool in cells.
Pyridoxine is stored mainly in the liver with lesser amounts stored in muscle and brain.
Biotransformation is hepatic and almost entirely as metabolites excreted in the urine. Excess beyond daily needs is excreted, largely unchanged in urine. In dialysis, removed by hemodialysis.
Cyanocobalamin is transported via specific B₁₂ binding proteins, transcobalamin I and II to the various tissues. The liver is the main organ for vitamin B₁₂ storage, excreted in the bile, undergoes extensive enterohepatic recycling, and part of a dose is excreted in the urine. Body retention is 55% of cyanocobalamin.
Hepatic extract antitoxic fraction, a purified exogenous 17 amino acids are metabolized in the liver and eliminated in the kidney via urine.
Elimination: Godex DS is excreted in the urine.