VENTAR Salbutamol 1mg / mL Nebulizing Solution 30mL
RXDRUG-DR-XY29245
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| CODE | Dosage Strength | Drug Packaging | Availability | Price | ||
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RXDRUG-DR-XY29245
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In stock
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₱17400 |
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Features
Brand
Ventar
Full Details
Dosage Strength
1mg /ml
Drug Ingredients
- Salbutamol
Drug Packaging
Nebulizing Solution 30ml
Generic Name
Salbutamol Sulfate
Dosage Form
Nebulizing Solution
Registration Number
DR-XY29245
Drug Classification
Prescription Drug (RX)
Description
Indications/Uses
For the relief of bronchospasm in bronchial asthma, chronic bronchitis, bronchiectasis, emphysema and other reversible obstructive pulmonary diseases.
Dosage/Direction for Use
Tablet & Syrup: To be taken every 6 to 8 hours.
Usual Adult Dose: 4 mg or 10 mL (2 teaspoonfuls) or as prescribed by the physician. If adequate bronchodilation is not obtained, each single dose may be gradually increased to as much as 8 mg or 20 mL (4 teaspoonfuls).
Some patients obtain adequate relief with 5 mL known to be unusually sensitive to β-adrenergic stimulant drugs. It is advisable to initiate treatment with 5 mL (1 teaspoonful) three or four times a day.
See table.
Usual Adult Dose: 4 mg or 10 mL (2 teaspoonfuls) or as prescribed by the physician. If adequate bronchodilation is not obtained, each single dose may be gradually increased to as much as 8 mg or 20 mL (4 teaspoonfuls).
Some patients obtain adequate relief with 5 mL known to be unusually sensitive to β-adrenergic stimulant drugs. It is advisable to initiate treatment with 5 mL (1 teaspoonful) three or four times a day.
See table.
Nebulizing solution: SALBUTAMOL (VENTAR) 1 mg/mL Nebulizing Solution for Inhalation is given undiluted using a nebulizer, under the direction of a physician. However, if prolonged inhalation is desirable (more than 10 minutes), the solution can be diluted with 0.9% sodium chloride solution.
Usual Adult and Adolescent Dose: The usual initial dose of salbutamol by wet inhalation is 2.5 mg to 5 mg. Treatment may be repeated up to 4 times daily. In adults, higher dosing up to 40 mg/day can be given under strict medical supervision in hospital for the treatment of severe airway obstruction.
Children up to 12 years of age: Dosage has not been established.
Note: As there may be adverse effects associated with excessive dosing, the dosage or frequency of administration should only be increased on medical advice.
Usual Adult and Adolescent Dose: The usual initial dose of salbutamol by wet inhalation is 2.5 mg to 5 mg. Treatment may be repeated up to 4 times daily. In adults, higher dosing up to 40 mg/day can be given under strict medical supervision in hospital for the treatment of severe airway obstruction.
Children up to 12 years of age: Dosage has not been established.
Note: As there may be adverse effects associated with excessive dosing, the dosage or frequency of administration should only be increased on medical advice.
Overdosage
Reports of overdosage with salbutamol have generally only described the features that may be expected with beta2 agonists such as tachycardia, CNS stimulation, tremor, hypokalaemia, and hyperglycaemia. Symptomatic treatment of the adverse effects has proved successful although it is unlikely to be required after repeated inhalation. Activated charcoal may be considered after oral overdose in patients who have taken a potentially toxic amount and present within 1 hour. The plasma potassium concentration and pulse rate have been found to correlate with the plasma concentration of salbutamol.
Administration
Should be taken on an empty stomach: Take 1 hr before or 2 hr after meals.
Contraindications
It is contraindicated to patients with history of hypersensitivity to Salbutamol.
Warnings
Salbutamol administered intravenously or orally during labor or delivery inhibits uterine contraction.
Patients taking this medication should consult their physician if they do not respond to the usual dose of this medication for reassessment of therapy.
Patients taking this medication should consult their physician if they do not respond to the usual dose of this medication for reassessment of therapy.
Special Precautions
Salbutamol should be administered with caution to patients suffering from thyrotoxicosis. Special care is advisable to patients receiving antihypertensive therapy. It should not be prescribed to patients under treatment with β-blockers. Great care in administration is also needed in patients with cardiac arrhythmias, coronary insufficiency, hypertension, ischemic heart disease, diabetes mellitus, hyperthyroidism, ketoacidosis, pheochromocytoma, sensitive to sympathomimetics. It should also be used with caution in patients undergoing anesthesia with cyclopropane or halothane, and those receiving cardiac glycosides, quinidine, or tricyclic antidepressants.
Use In Pregnancy & Lactation
Unnecessary administration of drugs during the first trimester of pregnancy is undesirable.
Adverse Reactions
To some patients, oral salbutamol may cause fine tremor of skeletal muscle particularly the hands, nausea, pounding heartbeat, nervousness or restlessness. The side effects are dose-related and are common to all β-adrenergic stimulants. In large doses than recommended, it may cause slight tachycardia, peripheral vasodilation and occasional headache have been reported. Few patients feel tense due also to the effect on skeletal muscle and not to direct CNS stimulation.
Drug Interactions
Use of salbutamol and other beta2 agonist with corticosteroids, diuretics, or xanthines increases the risk of hypokalaemia, and monitoring of potassium concentrations is recommended in severe asthma, where such combination therapy is common.
Caution For Usage
Nebulizing solution: Direction for Dilution/Prolonged Inhalation: The SALBUTAMOL (VENTAR) multiple dose bottle contains 15 mL or 30 mL nebulizing solution. Its content is equivalent to 15 mg or 30 mg Salbutamol (as sulfate).
1. Pipette 2.5 mL to 5 mL (equivalent to 2.5 mg and 5 mg salbutamol, as sulfate) of SALBUTAMOL (VENTAR) Nebulizing Solution from the bottle by using calibrated medicine dropper provided in the pack.
2. Drop the solution into an electric nebulizer and dilute it with 2 mL to 4 mL normal saline solution, and start inhalation. Any unused solution in the chamber of the nebulizer must be discarded.
3. Repeat the same procedure every 6 hours in 24-hour period, or as directed by the physician.
4. Diluted solution should be used within 24 hours when stored at room temperature or within 48 hours when stored in the refrigerator.
1. Pipette 2.5 mL to 5 mL (equivalent to 2.5 mg and 5 mg salbutamol, as sulfate) of SALBUTAMOL (VENTAR) Nebulizing Solution from the bottle by using calibrated medicine dropper provided in the pack.
2. Drop the solution into an electric nebulizer and dilute it with 2 mL to 4 mL normal saline solution, and start inhalation. Any unused solution in the chamber of the nebulizer must be discarded.
3. Repeat the same procedure every 6 hours in 24-hour period, or as directed by the physician.
4. Diluted solution should be used within 24 hours when stored at room temperature or within 48 hours when stored in the refrigerator.
Storage
Store at temperatures not exceeding 30°C. Protect from light.
Action
Pharmacology: Pharmacodynamics: Salbutamol (Ventar) is a direct-acting sympathomimetic agent with predominantly β-adrenergic activity and a selective action on β2-receptors. It is used as bronchodilator by stimulating β2-adrenergic receptors in the lungs to relax bronchial smooth muscle thereby relieving bronchospasm, increasing vital capacity, decreasing residual volume and reducing airway resistance. As a predominantly β-receptor stimulant, it has a more selective action. Its bronchodilating action being more prominent than its effect on the heart. Such β-adrenoceptor stimulants are preferred to other bronchodilator like isoprenaline for the management of asthma.
Pharmacokinetics: Tablet & Syrup: After oral administration, salbutamol is absorbed from the gastrointestinal tract and undergoes considerable first-pass metabolism to the phenolic sulphate. Both unchanged drug and conjugate are excreted primarily in the urine. The bioavailability of orally administered salbutamol is about 50%.
Nebulizing solution: When given by inhalation, 10 to 20% of the dose reaches the lower airways. The remainder is retained in the delivery system or is swallowed and absorbed from the gut. Salbutamol is rapidly excreted, mainly in the urine, as metabolites and unchanged drug; a smaller proportion is excreted in faeces.
Pharmacokinetics: Tablet & Syrup: After oral administration, salbutamol is absorbed from the gastrointestinal tract and undergoes considerable first-pass metabolism to the phenolic sulphate. Both unchanged drug and conjugate are excreted primarily in the urine. The bioavailability of orally administered salbutamol is about 50%.
Nebulizing solution: When given by inhalation, 10 to 20% of the dose reaches the lower airways. The remainder is retained in the delivery system or is swallowed and absorbed from the gut. Salbutamol is rapidly excreted, mainly in the urine, as metabolites and unchanged drug; a smaller proportion is excreted in faeces.
MedsGo Class
Antiasthmatic & COPD Preparations
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