Indications/Uses
Dexamethasone (Decilone) is indicated for the effective management of various inflammatory and allergic conditions which respond to corticosteroid therapy, such as: skin diseases, collagen diseases, blood dyscrasias, certain neoplastic diseases, and adrenocortical insufficiency.
Dosage/Direction for Use
Decilone: The dosage must be adjusted to the individual requirements depending upon the severity of the condition, anticipated duration of therapy, tolerance to the steroid, and according to the response obtained. The total daily dosage should be divided into 3 or 4 equal amounts.
Initial Suppressive Dosage: For initial suppressive therapy, a practical distinction between doses could be made in accordance with the form of a particular disorder.
Chronic Nonfatal Forms (e.g. rheumatoid arthritis, chronic bronchial asthma): 0.5 to 1 mg (1 to 2 tablets) daily.
Chronic Potentially Fatal Forms (e.g. disseminated lupus erythematosus, pemphigus, sarcoidosis): 2 to 4.5 mg (4 to 9 tablets) daily.
Acute Nonfatal Forms (e.g. seasonal allergies, dermatological and self-limited ocular disorders): 2 to 3 mg (4 to 6 tablets) daily.
Acute Potentially Fatal Forms (e.g. acute rheumatic fever, severe allergic reactions): 4 to 10 mg (8 to 20 tablets) daily.
Acute Leukemia, Nephrotic Syndrome, Acute Pemphigus: 10 to 15 mg (20 to 30 tablets) daily.
Maintenance Dosage: As soon as the symptoms have subsided, dosage should be gradually reduced to the minimum amount (usually 1 tablet daily) capable of producing adequate relief of symptoms.
Decilone Forte: The dosage must be adjusted to the individual requirements depending upon the severity of the condition, anticipated duration of therapy, tolerance to the steroid, and according to the response obtained. The total 48-hour requirement should be given as a single dose at 8 a.m. every other day.
Initial Suppressive Dosage: For initial suppressive therapy, a practical distinction between doses could be made in accordance with the form of a particular disorder.
Chronic Nonfatal Forms (e.g. rheumatoid arthritis, chronic bronchial asthma): 1-2 mg (¼ to ½ tablet every other day).
Chronic Potentially Fatal Forms (e.g. disseminated lupus erythematosus, pemphigus, sarcoidosis): 4-8 mg (1 to 2 tablets every other day).
Acute Nonfatal Forms (e.g. seasonal allergies, dermatological and self-limited ocular disorders): 4 to 6 mg (1 to 1½ tablet every other day).
Acute Potentially Fatal Forms (e.g. acute rheumatic fever, severe allergic reactions): 8-20 mg (2 to 5 tablets every other day).
Acute Leukemia, Nephrotic Syndrome, Acute Pemphigus: 20 to 30 mg (5 to 7½ tablets every other day).
Maintenance Dosage: As soon as the symptoms have subsided, dosage should be gradually reduced to the minimum amount capable of producing adequate relief of symptoms.
Initial Suppressive Dosage: For initial suppressive therapy, a practical distinction between doses could be made in accordance with the form of a particular disorder.
Chronic Nonfatal Forms (e.g. rheumatoid arthritis, chronic bronchial asthma): 0.5 to 1 mg (1 to 2 tablets) daily.
Chronic Potentially Fatal Forms (e.g. disseminated lupus erythematosus, pemphigus, sarcoidosis): 2 to 4.5 mg (4 to 9 tablets) daily.
Acute Nonfatal Forms (e.g. seasonal allergies, dermatological and self-limited ocular disorders): 2 to 3 mg (4 to 6 tablets) daily.
Acute Potentially Fatal Forms (e.g. acute rheumatic fever, severe allergic reactions): 4 to 10 mg (8 to 20 tablets) daily.
Acute Leukemia, Nephrotic Syndrome, Acute Pemphigus: 10 to 15 mg (20 to 30 tablets) daily.
Maintenance Dosage: As soon as the symptoms have subsided, dosage should be gradually reduced to the minimum amount (usually 1 tablet daily) capable of producing adequate relief of symptoms.
Decilone Forte: The dosage must be adjusted to the individual requirements depending upon the severity of the condition, anticipated duration of therapy, tolerance to the steroid, and according to the response obtained. The total 48-hour requirement should be given as a single dose at 8 a.m. every other day.
Initial Suppressive Dosage: For initial suppressive therapy, a practical distinction between doses could be made in accordance with the form of a particular disorder.
Chronic Nonfatal Forms (e.g. rheumatoid arthritis, chronic bronchial asthma): 1-2 mg (¼ to ½ tablet every other day).
Chronic Potentially Fatal Forms (e.g. disseminated lupus erythematosus, pemphigus, sarcoidosis): 4-8 mg (1 to 2 tablets every other day).
Acute Nonfatal Forms (e.g. seasonal allergies, dermatological and self-limited ocular disorders): 4 to 6 mg (1 to 1½ tablet every other day).
Acute Potentially Fatal Forms (e.g. acute rheumatic fever, severe allergic reactions): 8-20 mg (2 to 5 tablets every other day).
Acute Leukemia, Nephrotic Syndrome, Acute Pemphigus: 20 to 30 mg (5 to 7½ tablets every other day).
Maintenance Dosage: As soon as the symptoms have subsided, dosage should be gradually reduced to the minimum amount capable of producing adequate relief of symptoms.
Administration
Should be taken with food.
Special Precautions
Dexamethasone (Decilone) is essentially devoid of mineralocorticoid activity.
With large doses, however, the side effects attendant with corticosteroid therapy should be anticipated.
As with other corticosteroids, Dexamethasone (Decilone) should be given with caution in patients who have active, latent or questionably healed tuberculosis, diabetes mellitus, congestive heart failure, infectious diseases, peptic ulcer, fresh intestinal anastomoses, diverticulitis, thrombophlebitis, chronic renal failure, uremia, psychotic tendency, herpes simplex of the eye and in elderly persons.
With large doses, however, the side effects attendant with corticosteroid therapy should be anticipated.
As with other corticosteroids, Dexamethasone (Decilone) should be given with caution in patients who have active, latent or questionably healed tuberculosis, diabetes mellitus, congestive heart failure, infectious diseases, peptic ulcer, fresh intestinal anastomoses, diverticulitis, thrombophlebitis, chronic renal failure, uremia, psychotic tendency, herpes simplex of the eye and in elderly persons.
Adverse Reactions
Excessive mental stimulation, increased appetite, muscle twitching, increase in weight, tachycardia, insomnia and psychic disturbances have been reported.
Action
Pharmacologic Classification: Corticosteroid.
Pharmacology: Dexamethasone (Decilone) is a superior anti-inflammatory and anti-allergic agent which is more potent than other corticosteroids currently used.
Pharmacokinetics: Bioavailability: On equal-weight basis, dexamethasone (in Decilone) is six times more potent than triamcinolone or 6-methylprednisolone, six to eight times more potent than prednisone and prednisolone, 25 to 30 times more than hydrocortisone, and about 35 times more than cortisone. It is especially useful in those patients who have become refractory or have developed untoward reactions to other corticosteroids.
Decilone provides the distinct advantage of a greatly enhanced anti-inflammatory activity at a much lower dosage that is virtually devoid of sodium-retaining effect.
Pharmacology: Dexamethasone (Decilone) is a superior anti-inflammatory and anti-allergic agent which is more potent than other corticosteroids currently used.
Pharmacokinetics: Bioavailability: On equal-weight basis, dexamethasone (in Decilone) is six times more potent than triamcinolone or 6-methylprednisolone, six to eight times more potent than prednisone and prednisolone, 25 to 30 times more than hydrocortisone, and about 35 times more than cortisone. It is especially useful in those patients who have become refractory or have developed untoward reactions to other corticosteroids.
Decilone provides the distinct advantage of a greatly enhanced anti-inflammatory activity at a much lower dosage that is virtually devoid of sodium-retaining effect.
MedsGo Class
Corticosteroid Hormones
Features
Brand
Decilone Forte
Full Details
Dosage Strength
4mg
Drug Ingredients
- Dexamethasone
Drug Packaging
Tablet 1's
Generic Name
Dexamethasone
Dosage Form
Tablet
Registration Number
DR-6518
Drug Classification
Prescription Drug (RX)
View all variations as list
| CODE | Dosage Strength | Drug Packaging | Availability | Price | ||
|---|---|---|---|---|---|---|
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RXDRUG-DR-6518-1pc
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In stock
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₱3350 |