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Sellers of this product
Features
- Lynestrenol
Description
Indications/Uses
Dosage/Direction for Use
The interval between two pills should be 24 hours. Incorporate it to patient's daily routine-after evening meals or before going to sleep to easily remember to take it. A pack is good for 28 days.
Start a new pack the next day after taking the last pill.
Patient may continue taking the pill as long as wanted to avoid pregnancy. Do not skip taking the pill even if there is a brief pause from sexual activity.
Patient should only stop taking the pill after finishing a pack; otherwise bleeding may start.
Vomiting and persistent severe diarrhea can interfere with the absorption of the pill. If vomiting occurs within two hours of taking pill, another pill should be taken as soon as possible. If the replacement pill is not taken within 3 hours of the normal time of taking the pill, or in cases of persistent vomiting or severe diarrhea, a back-up method such as condom should be used during illness and for 2 days after recovery.
If patient missed a pill, it should be taken three hours after the 24-hour lapse to sustain its efficacy. Take the remaining pills as scheduled to avoid premature withdrawal bleeding. Follow the instructions on Missed Pills.
MISSED PILLS: The key to effective contraception is following the recommended dosage consistently.
Regularity in taking the pill is very important because contraceptive efficacy is reduced if a pill is delayed by more than three hours.
If the pill is less than three hours overdue, take it as soon as remembered. Resume taking the next scheduled pill. Patient will not need a back-up contraceptive method.
If the pill is more than three hours overdue, take it as soon as remembered and either abstain from sex or use condoms for the next two days. Resume taking the next scheduled pill. (See figure.)
Overdosage
Administration
Contraindications
Special Precautions
Adverse Reactions
Drug Interactions
Taking Lynestrenol (DAPHNE) with aprepitant and bosentan can result to a possible contraceptive failure.
Taking Lynestrenol (DAPHNE) with amprenavir, sitaxentan, atorvastatin and tacrolimus may increase the incidence of side effects.
Taking Lynestrenol (DAPHNE) with rufinamide can decrease the contraceptive efficacy.
Lynestrenol (DAPHNE) may enhance or reduce anticoagulant effect of coumarins, can increase clearance of some analgesics (e.g. paracetamol and morphine), can antagonize hypoglycemic effect of antidiabetics, and can antagonize anticoagulant effect of phenindione.
Lynestrenol (DAPHNE) can increase the plasma concentration of ciclosporin, selegiline, and possibly tizanidine and increasing the risk of toxicity.
Lynestrenol (DAPHNE) can reduce the plasma concentration of lamotrigine.
Storage
Action
Pharmacokinetics: Lynestrenol is a progestogen structurally related to norethistrone. Progestogens are derived from progesterone or 19-nortestosterone and with actions similar to those of progesterone. Lynestrenol is highly protein bound and undergo hepatic metabolism to various conjugates, which are excreted in urine.