GABATIN Gabapentin 100mg Capsule 1's
RXDRUG-DRP-6983-1pc
Discreet Packaging
FDA-registered Products
FDA-licensed Pharmacies
Indications/Uses
Gabapentin is antiepileptic effective in the treatment of partial seizure with or without secondary generalization and is used as adjunctive therapy in patients unresponsive to or intolerant to standard antiepileptic drugs. It is not generally considered effective for absence seizures. Although gabapentin is an analogue of gamma-aminobutyric acid (GABA), it is neither a GABA agonist nor antagonist and its mechanism of action is unknown. Gabapentin is also used in the treatment of neuropathic pain.
Dosage/Direction for Use
The initial dose for children 6 to 12 years of age for the treatment of epilepsy is 10 mg per kg body-weight on the first day of treatment, 20 mg per kg on the second day, and 25 to 35 mg per kg on the third day. Recommended maintenance doses are 900 mg daily for children weighing 26 to 36 kg and 1200 mg daily for those weighing 37 to 50 kg.
In the treatment of neuropathic pain in adults, doses should be titrated to a maximum of 1.8 g daily in three divided dose, in a similar manner to that recommended for the treatment of epilepsy in adults previously given.
Or as prescribed by the physician.
The initial adult dose of gabapentin for the treatment of epilepsy is 300 mg by mouth on the first day of treatment, 300 mg twice daily on the second day and 300 mg three times daily on the third day: thereafter the dose may be increased in increments of 300 mg daily until effective antiepileptic control is achieved which is usually within the range of 0.9 to 1.2 g daily. Higher doses up to a maximum of 2.4 g daily maybe required into more patients. The total daily dose should be taken in three equally divided doses and the maximum dosage intervals should not exceed 12 hours or as prescribed by the physician.
In the treatment of neuropathic pain in adults, doses should be titrated to a maximum of 1.8 g daily in three divided dose, in a similar manner to that recommended for the treatment of epilepsy in adults previously given.
Or as prescribed by the physician.
The initial adult dose of gabapentin for the treatment of epilepsy is 300 mg by mouth on the first day of treatment, 300 mg twice daily on the second day and 300 mg three times daily on the third day: thereafter the dose may be increased in increments of 300 mg daily until effective antiepileptic control is achieved which is usually within the range of 0.9 to 1.2 g daily. Higher doses up to a maximum of 2.4 g daily maybe required into more patients. The total daily dose should be taken in three equally divided doses and the maximum dosage intervals should not exceed 12 hours or as prescribed by the physician.
Administration
May be taken with or without food.
Special Precautions
Gabapentin should be used with caution in patients with a history of psychotic illness. It should also be used with caution in renal impairment; the manufacturer recommends dosage reduction in patients with reduced renal function or those undergoing haemodialysis. False positive readings have been reported with some urinary protein test in patients taking gabapentin.
Adverse Reactions
The most commonly reported adverse effects associated with gabapentin are somnolence, dizziness, ataxia, and fatigue. Nystagmus, tremor, diplopia, amblyopia, pharyngitis, dysarthria, weight gain, dyspepsia, amnesia, weakness, paraesthesia, arthralgia, purpura leucopenia, anxiety, and urinary-tract infection may occur less frequently. Rarely, pancreatitis, altered liver function tests, erythema multiforme, Stevens-Johnson Syndrome, rhinitis, nervousness, myalgia, headache, nausea, and vomiting, and blood glucose fluctuations in diabetics have been reported.
Drug Interactions
The absorption of gabapentin from the gastrointestinal tract is reduced by antacids and concomitant administration is therefore not recommended. Cimetidine has been reported to reduce the renal clearance of gabapentin but the manufacturers do not consider this to be of clinical importance.
Storage
Store at temperatures not exceeding 30°C.
Action
Pharmacology: Pharmacokinetics: Gabapentin is absorbed from the gastrointestinal tract by means of a saturable mechanism. Following multiple dosing peak plasma concentrations are usually achieved within 2 hours of administration and steady state achieved within 1 to 2 days. Gabapentin is not appreciably metabolized and most of a dose is excreted unchanged in the urine with the remainder appearing in faeces. Gabapentin is widely distributed throughout the body but binding to plasma proteins is minimal. The elimination half-life has been reported to be about 5 to 7 hours. Gabapentin is distributed into breast milk.
MedsGo Class
Anticonvulsants
Features
Brand
Gabatin
Full Details
Dosage Strength
100 mg
Drug Ingredients
- Gabapentin
Drug Packaging
Capsule 1's
Generic Name
Gabapentin
Dosage Form
Capsule
Registration Number
DRP-6983
Drug Classification
Prescription Drug (RX)
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