NEOBLOC Metoprolol Tartrate 50mg Tablet 1's
RXDRUG-DR-XY27497-1pc
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| CODE | Dosage Strength | Drug Packaging | Availability | Price | ||
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RXDRUG-DR-XY27497-1pc
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In stock
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₱700 |
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Features
Brand
Neobloc
Full Details
Dosage Strength
50 mg
Drug Ingredients
- Metoprolol
Drug Packaging
Tablet 1's
Generic Name
Metoprolol Tartrate
Dosage Form
Tablet
Registration Number
DR-XY27497
Drug Classification
Prescription Drug (RX)
Description
Indications/Uses
It is used in the management of hypertension, angina pectoris, cardiac arrhythmias, myocardial infarction, and heart failure. It is also used in the management of hyperthyroidism and in the prophylactic treatment of migraine.
Dosage/Direction for Use
The dose is dependent on the individual requirement and should be adjusted according to the response of the patient. Although the dose should be individualized, the usual initial oral adult dose is 50 mg twice a day or 100 mg once a day.
Dosage may be increased at one-week interval to as high as 400 mg a day according to the patient's response until optimum hypotensive effect is attained.
The usual oral maintenance dose is 100 mg to 400 mg daily. In some patients, once daily administration of 200 mg METOPROLOL tartrate (NEOBLOC) tablet is usually effective for maintenance dose.
METOPROLOL tartrate (NEOBLOC) tablet may be combined with other antihypertensive agents and/or diuretic combinations for therapeutic advantage.
Dosage may be increased at one-week interval to as high as 400 mg a day according to the patient's response until optimum hypotensive effect is attained.
The usual oral maintenance dose is 100 mg to 400 mg daily. In some patients, once daily administration of 200 mg METOPROLOL tartrate (NEOBLOC) tablet is usually effective for maintenance dose.
METOPROLOL tartrate (NEOBLOC) tablet may be combined with other antihypertensive agents and/or diuretic combinations for therapeutic advantage.
Overdosage
Symptoms: The symptoms of overdosage may include bradycardia and bradyarrhythmia, hypotension, cardiac insufficiency, cardiac conduction disturbances and bronchospasm.
Management: Care should be provided at a facility that can provide appropriate supporting measures, monitoring, and supervision.
If justified, gastric lavage and /or activated charcoal can be administered.
Atropine, adreno stimulating drugs or pacemaker to treat bradycardia and conduction disorders.
Hypotension, acute cardiac failure, and shock to be treated with suitable volume expansion, injection of glucagon (if necessary, followed by an intravenous infusion of glucagon), intravenous administration of adrenostimulating drugs such as dobutamine with α1 receptor agonistic drugs added in presence of vasodilation. Intravenous use of Ca2+ can also be considered.
Bronchospasm can usually be reversed by bronchodilators.
Management: Care should be provided at a facility that can provide appropriate supporting measures, monitoring, and supervision.
If justified, gastric lavage and /or activated charcoal can be administered.
Atropine, adreno stimulating drugs or pacemaker to treat bradycardia and conduction disorders.
Hypotension, acute cardiac failure, and shock to be treated with suitable volume expansion, injection of glucagon (if necessary, followed by an intravenous infusion of glucagon), intravenous administration of adrenostimulating drugs such as dobutamine with α1 receptor agonistic drugs added in presence of vasodilation. Intravenous use of Ca2+ can also be considered.
Bronchospasm can usually be reversed by bronchodilators.
Administration
May be taken with or without food.
Contraindications
METOPROLOL tartrate (NEOBLOC) is contraindicated in heart block, greater than first degree Atrioventricular (AV) block II and III degree, cardiogenic shock, overt cardiac failure and sinus bradycardia.
Warnings
Do not take other medicines, especially non-prescription sympathomimetics, unless discusses with physician.
Special Precautions
Abrupt withdrawal of the drug should be avoided and it should not be used by patients who have bronchospastic disease unless the patients does not respond to, or cannot tolerate other anti-hypertensive drug. In such cases, the lowest possible dose should be used and a β2-agonist should be administered concomitantly.
METOPROLOL tartrate may prolong hypoglycemic effect of insulin and should therefore be used with caution in diabetic patients especially those with labile diabetes. METOPROLOL tartrate therapy must be reported to the anaesthetist prior to general anaesthesia. Administration during the first trimester of pregnancy is not recommended.
METOPROLOL tartrate may prolong hypoglycemic effect of insulin and should therefore be used with caution in diabetic patients especially those with labile diabetes. METOPROLOL tartrate therapy must be reported to the anaesthetist prior to general anaesthesia. Administration during the first trimester of pregnancy is not recommended.
Use In Pregnancy & Lactation
Administration during the first trimester of pregnancy is not recommended.
Adverse Reactions
Gl & sleep pattern disturbances, headache, dizziness & weakness.
Storage
Store at temperatures not exceeding 30°C. Protect from light.
Action
Pharmacology: Mechanism of Action: Metoprolol is readily and completely absorbed from the gastrointestinal tract but is subject to considerable first-pass metabolism, with a bioavailability of about 50%. Peak plasma concentrations vary widely and occur about 1.5 to 2 hours after a single oral dose. It is moderately lipid-soluble. Metoprolol is widely distributed; it crosses the blood brain barrier and the placenta, and is distributed into breast milk. It is about 12% bound to plasma protein. It is extensively metabolized in the liver, mainly by the cytochrome P450 isoenzyme CYP2D6. The metabolites are excreted in the urine with only small amounts of unchanged metoprolol. The half-life of metoprolol in fast hydroxylators is stated to be 3 to 4 hours, whereas in poor hydroxylators it is about 7 hours.
MedsGo Class
Beta-Blockers
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