DAFLON 500 Diosmin / Hesperidin 450mg / 50mg Film-Coated Tablet 30's
NONRXDRUG-DR-XY12979
Discreet Packaging
FDA-registered Products
FDA-licensed Pharmacies
Indications/Uses
Daflon 500 mg: Recommended for treating venous circulation disorders (swollen legs, pain, nocturnal cramps) and for treating symptoms due to acute hemorrhoidal attack.
Daflon 1000: This medicine is a venotonic (it increases venous tone) and a vasculoprotector (it increases resistance in small blood vessels). This medicine is recommended for the treatment of venous circulation disorders (heavy legs, pain, restless legs) and functional symptoms related to acute hemorrhoidal attack. If the symptoms do not resolve within two weeks, it is essential to consult the doctor.
Daflon 1000: This medicine is a venotonic (it increases venous tone) and a vasculoprotector (it increases resistance in small blood vessels). This medicine is recommended for the treatment of venous circulation disorders (heavy legs, pain, restless legs) and functional symptoms related to acute hemorrhoidal attack. If the symptoms do not resolve within two weeks, it is essential to consult the doctor.
Dosage/Direction for Use
Daflon 500: Oral route. The tablets should be taken at meal times.
Venous insufficiency: 2 tablets daily, one at mid-day and one in the evening.
Acute hemorrhoidal attack: A 4-day course of 6 tablets daily, followed by 4 tablets daily over the next 3 days.
In all cases, strictly comply with the doctor's prescription.
Daflon 1000: Venous insufficiency: 1 tablet daily, at mealtime.
Hemorrhoidal attack: The recommended dose is 3 tablets per day for 4 days and then 2 tablets per day for the next 3 days, at mealtimes.
Oral route.
Missed dose: Not applicable.
Venous insufficiency: 2 tablets daily, one at mid-day and one in the evening.
Acute hemorrhoidal attack: A 4-day course of 6 tablets daily, followed by 4 tablets daily over the next 3 days.
In all cases, strictly comply with the doctor's prescription.
Daflon 1000: Venous insufficiency: 1 tablet daily, at mealtime.
Hemorrhoidal attack: The recommended dose is 3 tablets per day for 4 days and then 2 tablets per day for the next 3 days, at mealtimes.
Oral route.
Missed dose: Not applicable.
Overdosage
Symptoms: There is limited experience with Daflon overdose. The most frequently reported adverse events in overdose cases were gastrointestinal events (such as diarrhea, nausea, abdominal pain) and skin events (such as pruritus, rash).
Management: Management of overdose should consist in treatment of clinical symptoms.
If the patient taken more Daflon than he/she should, contact the doctor or pharmacist immediately.
Management: Management of overdose should consist in treatment of clinical symptoms.
If the patient taken more Daflon than he/she should, contact the doctor or pharmacist immediately.
Administration
Should be taken with food: Take at mealtimes.
Contraindications
Hypersensitivity to the active substance or to any of the excipients.
Special Precautions
Hemorrhoidal attack: If the hemorrhoid disorder persists for more than 15 days, it is essential that the patient consults a doctor.
The administration of this product does not preclude treatment for other anal conditions. The treatment must be short-term.
If symptoms do not subside promptly, a proctological examination should be performed and the treatment should be reviewed.
Venous circulation disorders: This treatment is at its most effective when combined with a healthy lifestyle.
Avoid exposure to the sun, heat, standing for too long, excess weight.
Walking, and wearing appropriate stockings when applicable, promote blood circulation.
The administration of this product does not preclude treatment for other anal conditions. The treatment must be short-term.
If symptoms do not subside promptly, a proctological examination should be performed and the treatment should be reviewed.
Venous circulation disorders: This treatment is at its most effective when combined with a healthy lifestyle.
Avoid exposure to the sun, heat, standing for too long, excess weight.
Walking, and wearing appropriate stockings when applicable, promote blood circulation.
Use In Pregnancy & Lactation
If patient is pregnant or breast-feeding, think may be pregnant or is planning to have a baby, ask the doctor or pharmacist for advice before taking this medicine.
Pregnancy: There are no limited amounts of data from the use of Micronised Purified Flavonoid Fraction in pregnant women.
Animal studies do not indicate reproductive toxicity.
As a precautionary measure, it is preferable to avoid the use of Daflon during pregnancy.
Breast-feeding: It is unknown whether the active substance/metabolites are excreted in human milk.
A risk to the newborns/infants cannot be excluded.
A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from Daflon therapy taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman.
Pregnancy: There are no limited amounts of data from the use of Micronised Purified Flavonoid Fraction in pregnant women.
Animal studies do not indicate reproductive toxicity.
As a precautionary measure, it is preferable to avoid the use of Daflon during pregnancy.
Breast-feeding: It is unknown whether the active substance/metabolites are excreted in human milk.
A risk to the newborns/infants cannot be excluded.
A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from Daflon therapy taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman.
Adverse Reactions
Like all medicines, this medicine can cause side effects, although not everybody gets them.
The frequency of the possible undesirable effects listed as follows is defined using the following system: Very common (affects more than 1 user out of 10); Common (affects 1 to 10 users out of 100); Uncommon (affects 1 to 10 users out of 1,000); Rare (affects 1 to 10 users out of 10,000); Very rare (affects less than 1 user out of 10,000); Frequency not known (cannot be estimated from the available data).
Nervous system disorders: Rare: dizziness, headaches, discomfort.
Gastrointestinal disorders: Common: diarrhea, dyspepsia (indigestion), nausea, vomiting. Uncommon: colitis. Frequency not known: abdominal pain.
Skin and subcutaneous tissue disorders: Rare: rash, pruritus (itching), urticaria (hives). Frequency not known: isolated face, eyelids, and lips edema. Exceptionally, Quincke's edema (angioedema).
The frequency of the possible undesirable effects listed as follows is defined using the following system: Very common (affects more than 1 user out of 10); Common (affects 1 to 10 users out of 100); Uncommon (affects 1 to 10 users out of 1,000); Rare (affects 1 to 10 users out of 10,000); Very rare (affects less than 1 user out of 10,000); Frequency not known (cannot be estimated from the available data).
Nervous system disorders: Rare: dizziness, headaches, discomfort.
Gastrointestinal disorders: Common: diarrhea, dyspepsia (indigestion), nausea, vomiting. Uncommon: colitis. Frequency not known: abdominal pain.
Skin and subcutaneous tissue disorders: Rare: rash, pruritus (itching), urticaria (hives). Frequency not known: isolated face, eyelids, and lips edema. Exceptionally, Quincke's edema (angioedema).
Caution For Usage
Do not throw away any medicines via wastewater of household waste.
Ask a pharmacist how to throw away medicines patients no longer use.
These measures will help protect the environment.
Ask a pharmacist how to throw away medicines patients no longer use.
These measures will help protect the environment.
Storage
Store at temperatures not exceeding 30°C.
Action
Pharmacology: Pharmacodynamics: Daflon exerts a dual action on the venous return system: at vein and venule level, it increases parietal tone and exerts an anti-stasis action; at the microcirculatory level, it reinforces capillary resistance and normalizes capillary permeability.
Pharmacokinetics: In humans, following oral administration of the medicinal product with carbon 14-labelled diosmin: excretion is essentially fecal and urinary excretion is on average 14% of the administered quantity, the elimination half-life is 11 hours, the product is highly metabolized as evidenced by the presence of various phenol acids in the urine.
Toxicology: Preclinical safety data: Non-clinical data reveal no special hazard for humans based on conventional studies of repeated dose toxicity, genotoxicity and toxicity to reproduction.
Pharmacokinetics: In humans, following oral administration of the medicinal product with carbon 14-labelled diosmin: excretion is essentially fecal and urinary excretion is on average 14% of the administered quantity, the elimination half-life is 11 hours, the product is highly metabolized as evidenced by the presence of various phenol acids in the urine.
Toxicology: Preclinical safety data: Non-clinical data reveal no special hazard for humans based on conventional studies of repeated dose toxicity, genotoxicity and toxicity to reproduction.
MedsGo Class
Anorectal Preparations / Phlebitis & Varicose Preparations
Features
Brand
DAFLON 500
Full Details
Dosage Strength
450 mg / 50 mg
Drug Ingredients
- Diosmin
- Hesperidin
Drug Packaging
Film-Coated Tablet 30's
Generic Name
Diosmin / Hesperidin
Dosage Form
Film-Coated Tablet
Registration Number
DR-XY12979
Drug Classification
Over-The-Counter (OTC)
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