Indications/Uses
For the relief of mild to moderate cough due to common colds, flu and mild to moderate acute bronchitis; for relief of reversible mild to moderate bronchospasm in adults and children 2 years of age and older with obstructive airway disease such as asthma and chronic bronchitis.
Dosage/Direction for Use
ASCOF for Kids: Syrup: Adult: 10 mL (2 teaspoonfuls) 3-4 times a day. Dose may be increased as needed, per physician's advice.
Children: 15 mg/kg/dose (or 0.25 mL/kg/dose) administered 3 times a day.
2-4 years old (10 to 15.5 kg): ½-1 teaspoonful 3 times a day.
4-6 years old (15.5 to 20 kg): 1 teaspoonful 3 times a day.
6-12 years old (20-40 kg): 1½-2 teaspoonfuls 3 times a day.
13 years old and above (over 40 kg): 2 teaspoonfuls 3 times a day.
Or as prescribed by the physician.
ASCOF Forte for Adults: Tablet/capsule: 300-600 mg three times a day to four times daily. Children 7-12 years: 300 mg three times a day to four times daily.
Syrup: Adults: 5 mL (1 teaspoon) 3 to 4 times a day. Dose may be increased as needed, per physician's advice.
Children (13 years old and above): 5 mL (1 teaspoon) 3 times a day. Dose may be increased as needed, per physician's advice.
Children (2 years to 12 years old): As prescribed by the physician.
Shake well before using.
Children: 15 mg/kg/dose (or 0.25 mL/kg/dose) administered 3 times a day.
2-4 years old (10 to 15.5 kg): ½-1 teaspoonful 3 times a day.
4-6 years old (15.5 to 20 kg): 1 teaspoonful 3 times a day.
6-12 years old (20-40 kg): 1½-2 teaspoonfuls 3 times a day.
13 years old and above (over 40 kg): 2 teaspoonfuls 3 times a day.
Or as prescribed by the physician.
ASCOF Forte for Adults: Tablet/capsule: 300-600 mg three times a day to four times daily. Children 7-12 years: 300 mg three times a day to four times daily.
Syrup: Adults: 5 mL (1 teaspoon) 3 to 4 times a day. Dose may be increased as needed, per physician's advice.
Children (13 years old and above): 5 mL (1 teaspoon) 3 times a day. Dose may be increased as needed, per physician's advice.
Children (2 years to 12 years old): As prescribed by the physician.
Shake well before using.
Overdosage
No overdose reported.
Administration
May be taken with or without food.
Special Precautions
Patients with allergy to Lagundi plant, to flavors such as grape or ginger. Safety among pregnant and lactating women has not been studied.
Use In Pregnancy & Lactation
Safety among pregnant and lactating women has not been studied.
Adverse Reactions
None were reported in the clinical trials of the syrup. Only mild side effects on a few patients, such as itchiness, nausea, vomiting and diarrhea without predominant complaint were reported for the tablets.
Storage
Store at temperatures not exceeding 30°C.
Action
Pharmacology: In a study conducted at the UP College of Pharmacy, Lagundi extract has been proven to inhibit the release of leukotrienes (a mediator in the inflamed process) from mast cells.
Lagundi is the only extensively studied cough remedy and antiasthma herbal preparation in the Philippines. The National Integrated Research Program on Medicinal Plants (NIRPOMP) has established in both animal and human studies, the wide margin of safety and efficacy of Lagundi as a cough remedy and antiasthma medicine.
Clinical Studies: Phase III double-blind placebo-controlled trial has shown bronchodilator and antitussive effects.
Numerous randomized double-blind, controlled clinical trials conducted at the PGH, UST and health centers showed that Lagundi syrup is effective in relieving acute cough of moderate severity.
A meta-analysis of clinical trials on Lagundi vs placebo among pediatric patients with acute cough of moderate severity demonstrated that Lagundi syrup resulted in better clinical improvement compared to placebo with a Peto odds ratio of 0.05 significance level.
Lagundi is the only extensively studied cough remedy and antiasthma herbal preparation in the Philippines. The National Integrated Research Program on Medicinal Plants (NIRPOMP) has established in both animal and human studies, the wide margin of safety and efficacy of Lagundi as a cough remedy and antiasthma medicine.
Clinical Studies: Phase III double-blind placebo-controlled trial has shown bronchodilator and antitussive effects.
Numerous randomized double-blind, controlled clinical trials conducted at the PGH, UST and health centers showed that Lagundi syrup is effective in relieving acute cough of moderate severity.
A meta-analysis of clinical trials on Lagundi vs placebo among pediatric patients with acute cough of moderate severity demonstrated that Lagundi syrup resulted in better clinical improvement compared to placebo with a Peto odds ratio of 0.05 significance level.
MedsGo Class
Antiasthmatic & COPD Preparations / Cough & Cold Preparations
Features
Brand
Ascof Forte
Full Details
Dosage Strength
600mg / 5ml
Drug Ingredients
- Vitex Negundo L.
Drug Packaging
Syrup 120ml
Generic Name
Vitex Negundo L.
Drug Flavor
Menthol
Dosage Form
Syrup
Registration Number
HMRP-31
Drug Classification
Household Remedy (HR)